Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication

3CLpro is a key proteinase for SARS-CoV-2 replication and serves as an important target for antiviral drug development. However, how its activity is regulated intracellularly is still obscure. In this study, we developed a 3CLpro protease activity reporter system to examine the impact of various fac...

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Autores principales: Liubing Du, Yanchun Xie, Kai Zheng, Niu Wang, Mingcheng Gao, Ting Yu, Liu Cao, QianQian Shao, Yong Zou, Wei Xia, Qianglin Fang, Bo Zhao, Deyin Guo, Xiaoxue Peng, Ji-An Pan
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/96766fb4cd0a4d358322855d4479906c
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