A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects

The genetic basis of cataract is not well understood. Here, the authors perform a genome-wide association multiethnic meta-analysis of cataract, finding 37 new loci and replicating known and new loci. They additionally perform sex-specific analyses, identifying new associations specific to women.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hélène Choquet, Ronald B. Melles, Deepti Anand, Jie Yin, Gabriel Cuellar-Partida, Wei Wang, 23andMe Research Team, Thomas J. Hoffmann, K. Saidas Nair, Pirro G. Hysi, Salil A. Lachke, Eric Jorgenson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9677633792df4445a49dcdc2a29801d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9677633792df4445a49dcdc2a29801d8
record_format	dspace
spelling	oai:doaj.org-article:9677633792df4445a49dcdc2a29801d82021-12-02T17:39:48ZA large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects10.1038/s41467-021-23873-82041-1723https://doaj.org/article/9677633792df4445a49dcdc2a29801d82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23873-8https://doaj.org/toc/2041-1723The genetic basis of cataract is not well understood. Here, the authors perform a genome-wide association multiethnic meta-analysis of cataract, finding 37 new loci and replicating known and new loci. They additionally perform sex-specific analyses, identifying new associations specific to women.Hélène ChoquetRonald B. MellesDeepti AnandJie YinGabriel Cuellar-PartidaWei Wang23andMe Research TeamThomas J. HoffmannK. Saidas NairPirro G. HysiSalil A. LachkeEric JorgensonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hélène Choquet Ronald B. Melles Deepti Anand Jie Yin Gabriel Cuellar-Partida Wei Wang 23andMe Research Team Thomas J. Hoffmann K. Saidas Nair Pirro G. Hysi Salil A. Lachke Eric Jorgenson A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
description	The genetic basis of cataract is not well understood. Here, the authors perform a genome-wide association multiethnic meta-analysis of cataract, finding 37 new loci and replicating known and new loci. They additionally perform sex-specific analyses, identifying new associations specific to women.
format	article
author	Hélène Choquet Ronald B. Melles Deepti Anand Jie Yin Gabriel Cuellar-Partida Wei Wang 23andMe Research Team Thomas J. Hoffmann K. Saidas Nair Pirro G. Hysi Salil A. Lachke Eric Jorgenson
author_facet	Hélène Choquet Ronald B. Melles Deepti Anand Jie Yin Gabriel Cuellar-Partida Wei Wang 23andMe Research Team Thomas J. Hoffmann K. Saidas Nair Pirro G. Hysi Salil A. Lachke Eric Jorgenson
author_sort	Hélène Choquet
title	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
title_short	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
title_full	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
title_fullStr	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
title_full_unstemmed	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects
title_sort	large multiethnic gwas meta-analysis of cataract identifies new risk loci and sex-specific effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9677633792df4445a49dcdc2a29801d8
work_keys_str_mv	AT helenechoquet alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ronaldbmelles alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT deeptianand alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT jieyin alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT gabrielcuellarpartida alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT weiwang alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT 23andmeresearchteam alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT thomasjhoffmann alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ksaidasnair alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT pirroghysi alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT salilalachke alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ericjorgenson alargemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT helenechoquet largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ronaldbmelles largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT deeptianand largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT jieyin largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT gabrielcuellarpartida largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT weiwang largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT 23andmeresearchteam largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT thomasjhoffmann largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ksaidasnair largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT pirroghysi largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT salilalachke largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects AT ericjorgenson largemultiethnicgwasmetaanalysisofcataractidentifiesnewrisklociandsexspecificeffects
_version_	1718379776842924032

A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects

Ejemplares similares