Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.

Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF(V600E)) are found in 3% of human non-small cell lung cancers. Contrary to KRAS m...

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Autores principales: Elena González-Sánchez, Juan Martín-Caballero, Juana María Flores, Javier Hernández-Losa, Ma Ángeles Montero, Javier Cortés, Roso Mares, Mariano Barbacid, Juan A Recio
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/9678441d61b544159212b4cfb22eb5a3
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