AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma

The Aurora kinases form a family of 3 genes encoding serine/threonine kinases and are involved in the regulation of cell division during the mitosis. This study was designed to investigate the prognostic role of Aurora kinases in hepatocellular carcinoma (HCC). In this study, we analyzed the express...

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Autores principales:	Jingchuan Xiao, Yingai Zhang
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Evolution QH359-425
Acceso en línea:	https://doaj.org/article/967a5ed67b3b4981af4cd9f8ccac7fe4
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id	oai:doaj.org-article:967a5ed67b3b4981af4cd9f8ccac7fe4
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spelling	oai:doaj.org-article:967a5ed67b3b4981af4cd9f8ccac7fe42021-12-01T02:04:01ZAURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma1176-934310.1177/11769343211057589https://doaj.org/article/967a5ed67b3b4981af4cd9f8ccac7fe42021-11-01T00:00:00Zhttps://doi.org/10.1177/11769343211057589https://doaj.org/toc/1176-9343The Aurora kinases form a family of 3 genes encoding serine/threonine kinases and are involved in the regulation of cell division during the mitosis. This study was designed to investigate the prognostic role of Aurora kinases in hepatocellular carcinoma (HCC). In this study, we analyzed the expression, overall survival (OS) data, promoter methylation level, and relationship with immunoinhibitors of Aurora kinases in patients with HCC from GEPIA2, UALCAN, OncoLnc, and TISIDB databases. Protein-protein interaction (PPI) network, gene ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and Reactome pathway analysis were performed using the STRING database and Cytoscape software. We found that the mRNA expression, stages of HCC, and OS of AURKA and AURKB in HCC tissues were significantly different from control tissues, but there were significant inconsistencies in promoter methylation level and relationship with immunoinhibitors for AURKA and AURKB. None of the above items were significantly different for AURKC. Furthermore, a hub module including AURKA, AURKB, and AURKC was identified within the PPI network constructed with the Molecular Complex Detection (MCODE) plug-in in Cytoscape software. Our results show that AURKB could be a potential biomarker for HCC prognosis.Jingchuan XiaoYingai ZhangSAGE PublishingarticleEvolutionQH359-425ENEvolutionary Bioinformatics, Vol 17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Evolution QH359-425
spellingShingle	Evolution QH359-425 Jingchuan Xiao Yingai Zhang AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
description	The Aurora kinases form a family of 3 genes encoding serine/threonine kinases and are involved in the regulation of cell division during the mitosis. This study was designed to investigate the prognostic role of Aurora kinases in hepatocellular carcinoma (HCC). In this study, we analyzed the expression, overall survival (OS) data, promoter methylation level, and relationship with immunoinhibitors of Aurora kinases in patients with HCC from GEPIA2, UALCAN, OncoLnc, and TISIDB databases. Protein-protein interaction (PPI) network, gene ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and Reactome pathway analysis were performed using the STRING database and Cytoscape software. We found that the mRNA expression, stages of HCC, and OS of AURKA and AURKB in HCC tissues were significantly different from control tissues, but there were significant inconsistencies in promoter methylation level and relationship with immunoinhibitors for AURKA and AURKB. None of the above items were significantly different for AURKC. Furthermore, a hub module including AURKA, AURKB, and AURKC was identified within the PPI network constructed with the Molecular Complex Detection (MCODE) plug-in in Cytoscape software. Our results show that AURKB could be a potential biomarker for HCC prognosis.
format	article
author	Jingchuan Xiao Yingai Zhang
author_facet	Jingchuan Xiao Yingai Zhang
author_sort	Jingchuan Xiao
title	AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
title_short	AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
title_full	AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
title_fullStr	AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
title_full_unstemmed	AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma
title_sort	aurkb as a promising prognostic biomarker in hepatocellular carcinoma
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/967a5ed67b3b4981af4cd9f8ccac7fe4
work_keys_str_mv	AT jingchuanxiao aurkbasapromisingprognosticbiomarkerinhepatocellularcarcinoma AT yingaizhang aurkbasapromisingprognosticbiomarkerinhepatocellularcarcinoma
_version_	1718405917236527104

AURKB as a Promising Prognostic Biomarker in Hepatocellular Carcinoma

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