Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study

Abstract Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported doctor-diagnosed asthma was categorized into active and non-active asthma....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin Jiang, Yi-Qian Sun, Arnulf Langhammer, Ben Michael Brumpton, Yue Chen, Tom IL Nilsen, Linda Leivseth, Sissel Gyrid Freim Wahl, Xiao-Mei Mai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/967a6ac5afeb487faffa41b1b45d5627
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:967a6ac5afeb487faffa41b1b45d5627
record_format	dspace
spelling	oai:doaj.org-article:967a6ac5afeb487faffa41b1b45d56272021-12-02T13:34:32ZAsthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study10.1038/s41598-021-84012-32045-2322https://doaj.org/article/967a6ac5afeb487faffa41b1b45d56272021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84012-3https://doaj.org/toc/2045-2322Abstract Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported doctor-diagnosed asthma was categorized into active and non-active asthma. Levels of asthma symptom control were classified into controlled and partially controlled (including partly controlled and uncontrolled) according to the Global Initiative for Asthma guidelines. Incident lung cancer cases were ascertained from the Cancer Registry of Norway. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for possible associations. Totally, 984 participants developed lung cancer during a median follow-up of 21.1 years. After adjustment for smoking and other potential confounders, an increased incidence of lung cancer was found for adults with partially controlled asthma (HR 1.39, 95% CI 1.00–1.92) compared with those without asthma at baseline. Adults with active asthma had a tendency of increased lung cancer incidence (HR 1.29, 95% CI 0.95–1.75). Sensitivity analyses indicated that the observed associations were less likely resulted from reverse causation or residual confounding by smoking. Our findings suggested that proper control of asthma symptoms might contribute to a reduced incidence of lung cancer.Lin JiangYi-Qian SunArnulf LanghammerBen Michael BrumptonYue ChenTom IL NilsenLinda LeivsethSissel Gyrid Freim WahlXiao-Mei MaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lin Jiang Yi-Qian Sun Arnulf Langhammer Ben Michael Brumpton Yue Chen Tom IL Nilsen Linda Leivseth Sissel Gyrid Freim Wahl Xiao-Mei Mai Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
description	Abstract Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported doctor-diagnosed asthma was categorized into active and non-active asthma. Levels of asthma symptom control were classified into controlled and partially controlled (including partly controlled and uncontrolled) according to the Global Initiative for Asthma guidelines. Incident lung cancer cases were ascertained from the Cancer Registry of Norway. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for possible associations. Totally, 984 participants developed lung cancer during a median follow-up of 21.1 years. After adjustment for smoking and other potential confounders, an increased incidence of lung cancer was found for adults with partially controlled asthma (HR 1.39, 95% CI 1.00–1.92) compared with those without asthma at baseline. Adults with active asthma had a tendency of increased lung cancer incidence (HR 1.29, 95% CI 0.95–1.75). Sensitivity analyses indicated that the observed associations were less likely resulted from reverse causation or residual confounding by smoking. Our findings suggested that proper control of asthma symptoms might contribute to a reduced incidence of lung cancer.
format	article
author	Lin Jiang Yi-Qian Sun Arnulf Langhammer Ben Michael Brumpton Yue Chen Tom IL Nilsen Linda Leivseth Sissel Gyrid Freim Wahl Xiao-Mei Mai
author_facet	Lin Jiang Yi-Qian Sun Arnulf Langhammer Ben Michael Brumpton Yue Chen Tom IL Nilsen Linda Leivseth Sissel Gyrid Freim Wahl Xiao-Mei Mai
author_sort	Lin Jiang
title	Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
title_short	Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
title_full	Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
title_fullStr	Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
title_full_unstemmed	Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
title_sort	asthma and asthma symptom control in relation to incidence of lung cancer in the hunt study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/967a6ac5afeb487faffa41b1b45d5627
work_keys_str_mv	AT linjiang asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT yiqiansun asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT arnulflanghammer asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT benmichaelbrumpton asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT yuechen asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT tomilnilsen asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT lindaleivseth asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT sisselgyridfreimwahl asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy AT xiaomeimai asthmaandasthmasymptomcontrolinrelationtoincidenceoflungcancerinthehuntstudy
_version_	1718392808776138752

Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study

Ejemplares similares