Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity.
Glutaminase C is a key metabolic enzyme, which is unregulated in many cancer systems and believed to play a central role in the Warburg effect, whereby cancer cells undergo changes to an altered metabolic profile. A long-standing hypothesis links enzymatic activity to the protein oligomeric state, h...
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Autores principales: | Magda Møller, Søren S Nielsen, Sekar Ramachandran, Yunxing Li, Giancarlo Tria, Werner Streicher, Maxim V Petoukhov, Richard A Cerione, Richard E Gillilan, Bente Vestergaard |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/9682e391a4e9416baea413fc6257853a |
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