Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of m...

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Autores principales:	Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/96839cce3bec43feb376e5547a803268
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spelling	oai:doaj.org-article:96839cce3bec43feb376e5547a8032682021-11-21T12:08:27ZPrecancerous liver diseases do not cause increased mutagenesis in liver stem cells10.1038/s42003-021-02839-y2399-3642https://doaj.org/article/96839cce3bec43feb376e5547a8032682021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02839-yhttps://doaj.org/toc/2399-3642Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of mutations, nor an alteration of mutation types in individual liver stem cells.Luan NguyenMyrthe JagerRuby LieshoutPetra E. de RuiterMauro D. LocatiNicolle BesselinkBastiaan van der RoestRoel JanssenSander BoymansJeroen de JongeJan N. M. IJzermansMichail DoukasMonique M. A. VerstegenRuben van BoxtelLuc J. W. van der LaanEdwin CuppenEwart KuijkNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Luan Nguyen Myrthe Jager Ruby Lieshout Petra E. de Ruiter Mauro D. Locati Nicolle Besselink Bastiaan van der Roest Roel Janssen Sander Boymans Jeroen de Jonge Jan N. M. IJzermans Michail Doukas Monique M. A. Verstegen Ruben van Boxtel Luc J. W. van der Laan Edwin Cuppen Ewart Kuijk Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
description	Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver diseases do not result in a detectable increase of mutations, nor an alteration of mutation types in individual liver stem cells.
format	article
author	Luan Nguyen Myrthe Jager Ruby Lieshout Petra E. de Ruiter Mauro D. Locati Nicolle Besselink Bastiaan van der Roest Roel Janssen Sander Boymans Jeroen de Jonge Jan N. M. IJzermans Michail Doukas Monique M. A. Verstegen Ruben van Boxtel Luc J. W. van der Laan Edwin Cuppen Ewart Kuijk
author_facet	Luan Nguyen Myrthe Jager Ruby Lieshout Petra E. de Ruiter Mauro D. Locati Nicolle Besselink Bastiaan van der Roest Roel Janssen Sander Boymans Jeroen de Jonge Jan N. M. IJzermans Michail Doukas Monique M. A. Verstegen Ruben van Boxtel Luc J. W. van der Laan Edwin Cuppen Ewart Kuijk
author_sort	Luan Nguyen
title	Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
title_short	Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
title_full	Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
title_fullStr	Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
title_full_unstemmed	Precancerous liver diseases do not cause increased mutagenesis in liver stem cells
title_sort	precancerous liver diseases do not cause increased mutagenesis in liver stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96839cce3bec43feb376e5547a803268
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Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

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