Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to cisplatin in p53-deficient tumours.
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Nature Portfolio
2020
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oai:doaj.org-article:968af14e7f93410d8098ad17f0bc993d2021-12-02T18:01:15ZEnhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints10.1038/s41467-020-17958-z2041-1723https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17958-zhttps://doaj.org/toc/2041-1723Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to cisplatin in p53-deficient tumours.Yi Wen KongErik C. DreadenSandra MorandellWen ZhouSanjeev S. DharaGanapathy SriramFred C. LamJesse C. PattersonMohiuddin QuadirAnh DinhKevin E. ShopsowitzShohreh VarmehÖmer H. YilmazStephen J. LippardH. Christian ReinhardtMichael T. HemannPaula T. HammondMichael B. YaffeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yi Wen Kong Erik C. Dreaden Sandra Morandell Wen Zhou Sanjeev S. Dhara Ganapathy Sriram Fred C. Lam Jesse C. Patterson Mohiuddin Quadir Anh Dinh Kevin E. Shopsowitz Shohreh Varmeh Ömer H. Yilmaz Stephen J. Lippard H. Christian Reinhardt Michael T. Hemann Paula T. Hammond Michael B. Yaffe Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| description |
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to cisplatin in p53-deficient tumours. |
| format |
article |
| author |
Yi Wen Kong Erik C. Dreaden Sandra Morandell Wen Zhou Sanjeev S. Dhara Ganapathy Sriram Fred C. Lam Jesse C. Patterson Mohiuddin Quadir Anh Dinh Kevin E. Shopsowitz Shohreh Varmeh Ömer H. Yilmaz Stephen J. Lippard H. Christian Reinhardt Michael T. Hemann Paula T. Hammond Michael B. Yaffe |
| author_facet |
Yi Wen Kong Erik C. Dreaden Sandra Morandell Wen Zhou Sanjeev S. Dhara Ganapathy Sriram Fred C. Lam Jesse C. Patterson Mohiuddin Quadir Anh Dinh Kevin E. Shopsowitz Shohreh Varmeh Ömer H. Yilmaz Stephen J. Lippard H. Christian Reinhardt Michael T. Hemann Paula T. Hammond Michael B. Yaffe |
| author_sort |
Yi Wen Kong |
| title |
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| title_short |
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| title_full |
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| title_fullStr |
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| title_full_unstemmed |
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| title_sort |
enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d |
| work_keys_str_mv |
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