FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION

Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors fo...

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Autores principales:	A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, M. I. Voevoda, V. N. Maximov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	myocardial infarction heat shock proteins gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/968b1aea9e444cb382ab9e649bcd3fd2
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spelling	oai:doaj.org-article:968b1aea9e444cb382ab9e649bcd3fd22021-11-18T08:03:41ZFEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION1563-06252313-741X10.15789/1563-0625-2011-1-87-92https://doaj.org/article/968b1aea9e444cb382ab9e649bcd3fd22014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/431https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors for MI. Frequency of HSP70-HOMTC heterozygous variant proved to be significantly higher in the group with Kettle body mass index (BMI) exceeding 25, as compared with a group of relatively healthy persons. By contrary, frequency of HSP70-HOMCC homozygosity in the MI group with BMI > 25 was significantly lower, than among healthy persons. When comparing genotype frequencies among MI patients with BMI > 25 and those with BMI<25, significance of the differences are retained, both for HSP70-HOMTC heterozygosity and HSP70-HOMCC homozygous state. (Med. Immunol., 2011, vol. 13, N 1, pp 87-92)A. V. ShevchenkoO. V. GolovanovaV. I. KonenkovM. I. VoevodaV. N. MaximovSPb RAACIarticlemyocardial infarctionheat shock proteinsgene polymorphismconventional risk factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 87-92 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardial infarction heat shock proteins gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607
spellingShingle	myocardial infarction heat shock proteins gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607 A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
description	Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors for MI. Frequency of HSP70-HOMTC heterozygous variant proved to be significantly higher in the group with Kettle body mass index (BMI) exceeding 25, as compared with a group of relatively healthy persons. By contrary, frequency of HSP70-HOMCC homozygosity in the MI group with BMI > 25 was significantly lower, than among healthy persons. When comparing genotype frequencies among MI patients with BMI > 25 and those with BMI<25, significance of the differences are retained, both for HSP70-HOMTC heterozygosity and HSP70-HOMCC homozygous state. (Med. Immunol., 2011, vol. 13, N 1, pp 87-92)
format	article
author	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov
author_facet	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov
author_sort	A. V. Shevchenko
title	FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
title_short	FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
title_full	FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
title_fullStr	FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
title_full_unstemmed	FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
title_sort	features of hsp70-2 and hsp70-ном gene polymorphism in the patients with a history of myocardial infarction
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/968b1aea9e444cb382ab9e649bcd3fd2
work_keys_str_mv	AT avshevchenko featuresofhsp702andhsp70nomgenepolymorphisminthepatientswithahistoryofmyocardialinfarction AT ovgolovanova featuresofhsp702andhsp70nomgenepolymorphisminthepatientswithahistoryofmyocardialinfarction AT vikonenkov featuresofhsp702andhsp70nomgenepolymorphisminthepatientswithahistoryofmyocardialinfarction AT mivoevoda featuresofhsp702andhsp70nomgenepolymorphisminthepatientswithahistoryofmyocardialinfarction AT vnmaximov featuresofhsp702andhsp70nomgenepolymorphisminthepatientswithahistoryofmyocardialinfarction
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FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION

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