Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis
Abstract The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used o...
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Nature Portfolio
2017
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oai:doaj.org-article:968e4f0928e24de69e0bc541788476762021-12-02T11:52:39ZElevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis10.1038/s41598-017-08283-52045-2322https://doaj.org/article/968e4f0928e24de69e0bc541788476762017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08283-5https://doaj.org/toc/2045-2322Abstract The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking. The levels of serum S. japonicum heat shock protein 60 (SjHSP60)-specific IgG and its subtype antibodies in animals (mice and rabbits) or patients with schistosomiasis were measured by ELISA. Liver pathologies in mice and rabbits were evaluated by gross pathology and histopathology, and hepatic fibrosis in patients was examined with ultrasound imaging. The results revealed that the titers of the total IgG and subtype IgG1 anti-SjHSP60 antibodies were positively correlated with the severity of liver pathology after S. japonicum infection. Our findings indicate that the SjHSP60 IgG and IgG1 antibody levels can be used as potential candidate biomarkers for evaluation of liver pathology in schistosomiasis; however, validation remains to be explored in further work.Xiaojun ChenWei LiYalin LiLei XuSha ZhouJifeng ZhuZhipeng XuFeng LiuDandan LinFei HuYuemin LiuWen JiangLiwang CuiChuan SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Xiaojun Chen Wei Li Yalin Li Lei Xu Sha Zhou Jifeng Zhu Zhipeng Xu Feng Liu Dandan Lin Fei Hu Yuemin Liu Wen Jiang Liwang Cui Chuan Su Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| description |
Abstract The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking. The levels of serum S. japonicum heat shock protein 60 (SjHSP60)-specific IgG and its subtype antibodies in animals (mice and rabbits) or patients with schistosomiasis were measured by ELISA. Liver pathologies in mice and rabbits were evaluated by gross pathology and histopathology, and hepatic fibrosis in patients was examined with ultrasound imaging. The results revealed that the titers of the total IgG and subtype IgG1 anti-SjHSP60 antibodies were positively correlated with the severity of liver pathology after S. japonicum infection. Our findings indicate that the SjHSP60 IgG and IgG1 antibody levels can be used as potential candidate biomarkers for evaluation of liver pathology in schistosomiasis; however, validation remains to be explored in further work. |
| format |
article |
| author |
Xiaojun Chen Wei Li Yalin Li Lei Xu Sha Zhou Jifeng Zhu Zhipeng Xu Feng Liu Dandan Lin Fei Hu Yuemin Liu Wen Jiang Liwang Cui Chuan Su |
| author_facet |
Xiaojun Chen Wei Li Yalin Li Lei Xu Sha Zhou Jifeng Zhu Zhipeng Xu Feng Liu Dandan Lin Fei Hu Yuemin Liu Wen Jiang Liwang Cui Chuan Su |
| author_sort |
Xiaojun Chen |
| title |
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| title_short |
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| title_full |
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| title_fullStr |
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| title_full_unstemmed |
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis |
| title_sort |
elevated serum antibody against schistosoma japonicum hsp60 as a promising biomarker for liver pathology in schistosomiasis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/968e4f0928e24de69e0bc54178847676 |
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