Cytotoxic Effect In Vitro of Acalypha monostachya Extracts over Human Tumor Cell Lines

Acalypha monostachya (A. monostachya) is a plant that is used in traditional medicine as a cancer treatment; however, its effect has not been validated. In this study, the potential cytotoxic effects and morphological changes of A. monostachya were evaluated in...

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Autores principales:	Gloria A. Guillén-Meléndez, Sheila A. Villa-Cedillo, Raymundo A. Pérez-Hernández, Uziel Castillo-Velázquez, Daniel Salas-Treviño, Odila Saucedo-Cárdenas, Roberto Montes-de-Oca-Luna, Christian A. Gómez-Tristán, Aimé Jazmín Garza-Arredondo, Diana Elisa Zamora-Ávila, María de Jesús Loera-Arias, Adolfo Soto-Domínguez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human tumor cell lines cytotoxic effect plant extracts <i>Acalypha monostachya</i> Botany QK1-989
Acceso en línea:	https://doaj.org/article/9691014110cf4fa7bfa2c1f63946642f
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spelling	oai:doaj.org-article:9691014110cf4fa7bfa2c1f63946642f2021-11-25T18:45:20ZCytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines10.3390/plants101123262223-7747https://doaj.org/article/9691014110cf4fa7bfa2c1f63946642f2021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2326https://doaj.org/toc/2223-7747<i>Acalypha monostachya (A. monostachya)</i> is a plant that is used in traditional medicine as a cancer treatment; however, its effect has not been validated. In this study, the potential cytotoxic effects and morphological changes of <i>A. monostachya</i> were evaluated in human tumor cell lines. The aqueous (AE), methanolic (ME), and hexane (HE) extracts were obtained, and flavonoid-type phenolic compounds were detected, which indicates an antineoplastic effect. We observed a time-dependent and concentration-selective toxicity in human tumor cells. Additionally, the ME and HE showed the greatest cytotoxic effect at minimum concentrations compared to the AE, which showed this effect at the highest concentrations. All extracts induced significant morphological changes in tumor cells. The HeLa (cervix carcinoma) cells were more sensitive compared to the MDA-MB-231 (triple-negative breast cancer) cells. In conclusion, we demonstrated a cytotoxic in vitro effect of <i>A. monostachya</i> extracts in tumoral human cell lines. These results show the potential antineoplastic effects of <i>A. monostachya</i> in vitro. Hereafter, our lab team will continue working to usefully isolate and obtain the specific compounds of <i>A. monostachya</i> extracts with cytotoxic effects on tumor cells to find more alternatives for cancer treatment.Gloria A. Guillén-MeléndezSheila A. Villa-CedilloRaymundo A. Pérez-HernándezUziel Castillo-VelázquezDaniel Salas-TreviñoOdila Saucedo-CárdenasRoberto Montes-de-Oca-LunaChristian A. Gómez-TristánAimé Jazmín Garza-ArredondoDiana Elisa Zamora-ÁvilaMaría de Jesús Loera-AriasAdolfo Soto-DomínguezMDPI AGarticlehuman tumor cell linescytotoxic effectplant extracts<i>Acalypha monostachya</i>BotanyQK1-989ENPlants, Vol 10, Iss 2326, p 2326 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human tumor cell lines cytotoxic effect plant extracts <i>Acalypha monostachya</i> Botany QK1-989
spellingShingle	human tumor cell lines cytotoxic effect plant extracts <i>Acalypha monostachya</i> Botany QK1-989 Gloria A. Guillén-Meléndez Sheila A. Villa-Cedillo Raymundo A. Pérez-Hernández Uziel Castillo-Velázquez Daniel Salas-Treviño Odila Saucedo-Cárdenas Roberto Montes-de-Oca-Luna Christian A. Gómez-Tristán Aimé Jazmín Garza-Arredondo Diana Elisa Zamora-Ávila María de Jesús Loera-Arias Adolfo Soto-Domínguez Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
description	<i>Acalypha monostachya (A. monostachya)</i> is a plant that is used in traditional medicine as a cancer treatment; however, its effect has not been validated. In this study, the potential cytotoxic effects and morphological changes of <i>A. monostachya</i> were evaluated in human tumor cell lines. The aqueous (AE), methanolic (ME), and hexane (HE) extracts were obtained, and flavonoid-type phenolic compounds were detected, which indicates an antineoplastic effect. We observed a time-dependent and concentration-selective toxicity in human tumor cells. Additionally, the ME and HE showed the greatest cytotoxic effect at minimum concentrations compared to the AE, which showed this effect at the highest concentrations. All extracts induced significant morphological changes in tumor cells. The HeLa (cervix carcinoma) cells were more sensitive compared to the MDA-MB-231 (triple-negative breast cancer) cells. In conclusion, we demonstrated a cytotoxic in vitro effect of <i>A. monostachya</i> extracts in tumoral human cell lines. These results show the potential antineoplastic effects of <i>A. monostachya</i> in vitro. Hereafter, our lab team will continue working to usefully isolate and obtain the specific compounds of <i>A. monostachya</i> extracts with cytotoxic effects on tumor cells to find more alternatives for cancer treatment.
format	article
author	Gloria A. Guillén-Meléndez Sheila A. Villa-Cedillo Raymundo A. Pérez-Hernández Uziel Castillo-Velázquez Daniel Salas-Treviño Odila Saucedo-Cárdenas Roberto Montes-de-Oca-Luna Christian A. Gómez-Tristán Aimé Jazmín Garza-Arredondo Diana Elisa Zamora-Ávila María de Jesús Loera-Arias Adolfo Soto-Domínguez
author_facet	Gloria A. Guillén-Meléndez Sheila A. Villa-Cedillo Raymundo A. Pérez-Hernández Uziel Castillo-Velázquez Daniel Salas-Treviño Odila Saucedo-Cárdenas Roberto Montes-de-Oca-Luna Christian A. Gómez-Tristán Aimé Jazmín Garza-Arredondo Diana Elisa Zamora-Ávila María de Jesús Loera-Arias Adolfo Soto-Domínguez
author_sort	Gloria A. Guillén-Meléndez
title	Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
title_short	Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
title_full	Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
title_fullStr	Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
title_full_unstemmed	Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines
title_sort	cytotoxic effect in vitro of <i>acalypha monostachya</i> extracts over human tumor cell lines
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9691014110cf4fa7bfa2c1f63946642f
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Cytotoxic Effect In Vitro of <i>Acalypha monostachya</i> Extracts over Human Tumor Cell Lines

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