Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer
Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.
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Nature Portfolio
2017
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oai:doaj.org-article:96919909da284f8fa860db3ad18b5b3a2021-12-02T17:06:11ZEvasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer10.1038/s41467-017-00147-w2041-1723https://doaj.org/article/96919909da284f8fa860db3ad18b5b3a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00147-whttps://doaj.org/toc/2041-1723Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.Manav KorpalXiaoling PuyangZhenhua Jeremy WuRoland SeilerCraig FurmanHtoo Zarni OoMichael SeilerSean IrwinVanitha SubramanianJaya Julie JoshiChris K. WangVictoria RimkunasDavide TortoraHua YangNamita KumarGalina KuznetsovMark MatijevicJesse ChowPavan KumarJian ZouJacob FealaLaura CorsonRyan HenryAnand SelvarajAllison DavisKristjan BloudoffJames DouglasBernhard KissMorgan RobertsLadan FazliPeter C. BlackPeter FekkesPeter G. SmithMarkus WarmuthLihua YuMing-Hong HaoNicholas LarsenMads DaugaardPing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Manav Korpal Xiaoling Puyang Zhenhua Jeremy Wu Roland Seiler Craig Furman Htoo Zarni Oo Michael Seiler Sean Irwin Vanitha Subramanian Jaya Julie Joshi Chris K. Wang Victoria Rimkunas Davide Tortora Hua Yang Namita Kumar Galina Kuznetsov Mark Matijevic Jesse Chow Pavan Kumar Jian Zou Jacob Feala Laura Corson Ryan Henry Anand Selvaraj Allison Davis Kristjan Bloudoff James Douglas Bernhard Kiss Morgan Roberts Ladan Fazli Peter C. Black Peter Fekkes Peter G. Smith Markus Warmuth Lihua Yu Ming-Hong Hao Nicholas Larsen Mads Daugaard Ping Zhu Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| description |
Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment. |
| format |
article |
| author |
Manav Korpal Xiaoling Puyang Zhenhua Jeremy Wu Roland Seiler Craig Furman Htoo Zarni Oo Michael Seiler Sean Irwin Vanitha Subramanian Jaya Julie Joshi Chris K. Wang Victoria Rimkunas Davide Tortora Hua Yang Namita Kumar Galina Kuznetsov Mark Matijevic Jesse Chow Pavan Kumar Jian Zou Jacob Feala Laura Corson Ryan Henry Anand Selvaraj Allison Davis Kristjan Bloudoff James Douglas Bernhard Kiss Morgan Roberts Ladan Fazli Peter C. Black Peter Fekkes Peter G. Smith Markus Warmuth Lihua Yu Ming-Hong Hao Nicholas Larsen Mads Daugaard Ping Zhu |
| author_facet |
Manav Korpal Xiaoling Puyang Zhenhua Jeremy Wu Roland Seiler Craig Furman Htoo Zarni Oo Michael Seiler Sean Irwin Vanitha Subramanian Jaya Julie Joshi Chris K. Wang Victoria Rimkunas Davide Tortora Hua Yang Namita Kumar Galina Kuznetsov Mark Matijevic Jesse Chow Pavan Kumar Jian Zou Jacob Feala Laura Corson Ryan Henry Anand Selvaraj Allison Davis Kristjan Bloudoff James Douglas Bernhard Kiss Morgan Roberts Ladan Fazli Peter C. Black Peter Fekkes Peter G. Smith Markus Warmuth Lihua Yu Ming-Hong Hao Nicholas Larsen Mads Daugaard Ping Zhu |
| author_sort |
Manav Korpal |
| title |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| title_short |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| title_full |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| title_fullStr |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| title_full_unstemmed |
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer |
| title_sort |
evasion of immunosurveillance by genomic alterations of pparγ/rxrα in bladder cancer |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/96919909da284f8fa860db3ad18b5b3a |
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