Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective usin...
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Nature Portfolio
2020
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oai:doaj.org-article:96930173c51d4c149db6d9fcbe66090f2021-12-02T15:33:32ZSingle-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity10.1038/s41467-019-13972-y2041-1723https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13972-yhttps://doaj.org/toc/2041-1723Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART.Mariya B. ShapiroTracy CheeverDelphine C. MalherbeShilpi PandeyJason ReedEun Sung YangKeyun WangAmarendra PeguXuejun ChenDon SiessDavid BurkeHeidi HendersonRebecca LewinsohnMiranda FischerJeffrey J. StantonMichael K. AxthelmChristoph KahlByung ParkAnne D. LewisJonah B. SachaJohn R. MascolaAnn J. HessellNancy L. HaigwoodNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mariya B. Shapiro Tracy Cheever Delphine C. Malherbe Shilpi Pandey Jason Reed Eun Sung Yang Keyun Wang Amarendra Pegu Xuejun Chen Don Siess David Burke Heidi Henderson Rebecca Lewinsohn Miranda Fischer Jeffrey J. Stanton Michael K. Axthelm Christoph Kahl Byung Park Anne D. Lewis Jonah B. Sacha John R. Mascola Ann J. Hessell Nancy L. Haigwood Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| description |
Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART. |
| format |
article |
| author |
Mariya B. Shapiro Tracy Cheever Delphine C. Malherbe Shilpi Pandey Jason Reed Eun Sung Yang Keyun Wang Amarendra Pegu Xuejun Chen Don Siess David Burke Heidi Henderson Rebecca Lewinsohn Miranda Fischer Jeffrey J. Stanton Michael K. Axthelm Christoph Kahl Byung Park Anne D. Lewis Jonah B. Sacha John R. Mascola Ann J. Hessell Nancy L. Haigwood |
| author_facet |
Mariya B. Shapiro Tracy Cheever Delphine C. Malherbe Shilpi Pandey Jason Reed Eun Sung Yang Keyun Wang Amarendra Pegu Xuejun Chen Don Siess David Burke Heidi Henderson Rebecca Lewinsohn Miranda Fischer Jeffrey J. Stanton Michael K. Axthelm Christoph Kahl Byung Park Anne D. Lewis Jonah B. Sacha John R. Mascola Ann J. Hessell Nancy L. Haigwood |
| author_sort |
Mariya B. Shapiro |
| title |
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| title_short |
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| title_full |
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| title_fullStr |
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| title_full_unstemmed |
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity |
| title_sort |
single-dose bnab cocktail or abbreviated art post-exposure regimens achieve tight shiv control without adaptive immunity |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f |
| work_keys_str_mv |
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