Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective usin...

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Autores principales: Mariya B. Shapiro, Tracy Cheever, Delphine C. Malherbe, Shilpi Pandey, Jason Reed, Eun Sung Yang, Keyun Wang, Amarendra Pegu, Xuejun Chen, Don Siess, David Burke, Heidi Henderson, Rebecca Lewinsohn, Miranda Fischer, Jeffrey J. Stanton, Michael K. Axthelm, Christoph Kahl, Byung Park, Anne D. Lewis, Jonah B. Sacha, John R. Mascola, Ann J. Hessell, Nancy L. Haigwood
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f
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spelling oai:doaj.org-article:96930173c51d4c149db6d9fcbe66090f2021-12-02T15:33:32ZSingle-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity10.1038/s41467-019-13972-y2041-1723https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13972-yhttps://doaj.org/toc/2041-1723Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART.Mariya B. ShapiroTracy CheeverDelphine C. MalherbeShilpi PandeyJason ReedEun Sung YangKeyun WangAmarendra PeguXuejun ChenDon SiessDavid BurkeHeidi HendersonRebecca LewinsohnMiranda FischerJeffrey J. StantonMichael K. AxthelmChristoph KahlByung ParkAnne D. LewisJonah B. SachaJohn R. MascolaAnn J. HessellNancy L. HaigwoodNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mariya B. Shapiro
Tracy Cheever
Delphine C. Malherbe
Shilpi Pandey
Jason Reed
Eun Sung Yang
Keyun Wang
Amarendra Pegu
Xuejun Chen
Don Siess
David Burke
Heidi Henderson
Rebecca Lewinsohn
Miranda Fischer
Jeffrey J. Stanton
Michael K. Axthelm
Christoph Kahl
Byung Park
Anne D. Lewis
Jonah B. Sacha
John R. Mascola
Ann J. Hessell
Nancy L. Haigwood
Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
description Broadly neutralizing antibodies (bNAbs) are being evaluated for HIV post-exposure prophylaxis (PEP) in the setting of vertical transmission. Here, using a macaque model of perinatal SHIV infection, the authors show that PEP for infant macaques within 30–48 h of SHIV exposure is highly effective using either bNAbs or ART.
format article
author Mariya B. Shapiro
Tracy Cheever
Delphine C. Malherbe
Shilpi Pandey
Jason Reed
Eun Sung Yang
Keyun Wang
Amarendra Pegu
Xuejun Chen
Don Siess
David Burke
Heidi Henderson
Rebecca Lewinsohn
Miranda Fischer
Jeffrey J. Stanton
Michael K. Axthelm
Christoph Kahl
Byung Park
Anne D. Lewis
Jonah B. Sacha
John R. Mascola
Ann J. Hessell
Nancy L. Haigwood
author_facet Mariya B. Shapiro
Tracy Cheever
Delphine C. Malherbe
Shilpi Pandey
Jason Reed
Eun Sung Yang
Keyun Wang
Amarendra Pegu
Xuejun Chen
Don Siess
David Burke
Heidi Henderson
Rebecca Lewinsohn
Miranda Fischer
Jeffrey J. Stanton
Michael K. Axthelm
Christoph Kahl
Byung Park
Anne D. Lewis
Jonah B. Sacha
John R. Mascola
Ann J. Hessell
Nancy L. Haigwood
author_sort Mariya B. Shapiro
title Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
title_short Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
title_full Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
title_fullStr Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
title_full_unstemmed Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity
title_sort single-dose bnab cocktail or abbreviated art post-exposure regimens achieve tight shiv control without adaptive immunity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/96930173c51d4c149db6d9fcbe66090f
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