ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS

Abstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease o...

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Autores principales:	A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, M. I. Voevoda, V. N. Maximov, O. M. Tolkacheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	myocardial infarction polymorphism il-6 cardiovascular risk factors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9695a7cc11204797b15151cf32e1b50d
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spelling	oai:doaj.org-article:9695a7cc11204797b15151cf32e1b50d2021-11-18T08:03:40ZANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS1563-06252313-741X10.15789/1563-0625-2009-6-557-566https://doaj.org/article/9695a7cc11204797b15151cf32e1b50d2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/367https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease of -174 GG genotype in the patients with MI. Frequency of the same genotype is decreased among smoking patients as compared to healthy non-smokers. On other hand, an increased body weight and arterial pressure indexes increase is found in IL6-174 G patients, versus healthy population. Hence, the analyzed IL6 (-174 G/C) polymorphism may be considered as an additional predisposition factor for development of vascular damage.A. V. ShevchenkoO. V. GolovanovaV. I. KonenkovM. I. VoevodaV. N. MaximovO. M. TolkachevaSPb RAACIarticlemyocardial infarctionpolymorphism il-6cardiovascular risk factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 557-566 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardial infarction polymorphism il-6 cardiovascular risk factors Immunologic diseases. Allergy RC581-607
spellingShingle	myocardial infarction polymorphism il-6 cardiovascular risk factors Immunologic diseases. Allergy RC581-607 A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
description	Abstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease of -174 GG genotype in the patients with MI. Frequency of the same genotype is decreased among smoking patients as compared to healthy non-smokers. On other hand, an increased body weight and arterial pressure indexes increase is found in IL6-174 G patients, versus healthy population. Hence, the analyzed IL6 (-174 G/C) polymorphism may be considered as an additional predisposition factor for development of vascular damage.
format	article
author	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva
author_facet	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva
author_sort	A. V. Shevchenko
title	ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
title_short	ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
title_full	ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
title_fullStr	ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
title_full_unstemmed	ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
title_sort	analysis of correlation between il 6 gene polymorphism (-174 g /c) and classic risk factors in patients with previous myocardial infarctions
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9695a7cc11204797b15151cf32e1b50d
work_keys_str_mv	AT avshevchenko analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT ovgolovanova analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT vikonenkov analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT mivoevoda analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT vnmaximov analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT omtolkacheva analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions
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ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS

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