Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens

ABSTRACT Traditional approaches to harnessing the immune system to confront infectious diseases depend on vaccines, which have generally proven highly effective, but for many infections these either are not available or are of limited effectiveness. Although antibiotic therapy has been extremely suc...

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Autor principal:	Michael W. Russell
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9695eb78c0dd4af18e8f28e912b08f7d
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spelling	oai:doaj.org-article:9695eb78c0dd4af18e8f28e912b08f7d2021-11-15T15:49:03ZThinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens10.1128/mBio.00382-152150-7511https://doaj.org/article/9695eb78c0dd4af18e8f28e912b08f7d2015-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00382-15https://doaj.org/toc/2150-7511ABSTRACT Traditional approaches to harnessing the immune system to confront infectious diseases depend on vaccines, which have generally proven highly effective, but for many infections these either are not available or are of limited effectiveness. Although antibiotic therapy has been extremely successful in reducing the burden of bacterial disease, the emergence of resistance among several important pathogens threatens to undermine this accomplishment, and despite some successes chemotherapeutic treatments for viral, fungal, and parasitic infections are more limited. Understanding the mechanisms whereby pathogens manipulate the immune system to favor their survival, or exploit weaknesses in host immunity, can lead to novel approaches for the treatment of infections by redirecting host immune responses against the pathogen. Such treatments may be most effectively applied at the mucosal locations which are frequently the sites of initial infection and may also suggest new approaches for vaccine development.Michael W. RussellAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 3 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Michael W. Russell Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
description	ABSTRACT Traditional approaches to harnessing the immune system to confront infectious diseases depend on vaccines, which have generally proven highly effective, but for many infections these either are not available or are of limited effectiveness. Although antibiotic therapy has been extremely successful in reducing the burden of bacterial disease, the emergence of resistance among several important pathogens threatens to undermine this accomplishment, and despite some successes chemotherapeutic treatments for viral, fungal, and parasitic infections are more limited. Understanding the mechanisms whereby pathogens manipulate the immune system to favor their survival, or exploit weaknesses in host immunity, can lead to novel approaches for the treatment of infections by redirecting host immune responses against the pathogen. Such treatments may be most effectively applied at the mucosal locations which are frequently the sites of initial infection and may also suggest new approaches for vaccine development.
format	article
author	Michael W. Russell
author_facet	Michael W. Russell
author_sort	Michael W. Russell
title	Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
title_short	Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
title_full	Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
title_fullStr	Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
title_full_unstemmed	Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens
title_sort	thinking globally, acting locally: harnessing the immune system to deal with recalcitrant pathogens
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/9695eb78c0dd4af18e8f28e912b08f7d
work_keys_str_mv	AT michaelwrussell thinkinggloballyactinglocallyharnessingtheimmunesystemtodealwithrecalcitrantpathogens
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Thinking Globally, Acting Locally: Harnessing the Immune System to Deal with Recalcitrant Pathogens

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