<italic toggle="yes">Bordetella</italic> Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca<sub>V</sub>3.1 as the Cell Surface Receptor

<italic toggle="yes">Bordetella</italic> Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca<sub>V</sub>3.1 as the Cell Surface Receptor

ABSTRACT Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca2+ channel CaV3.1 as the DNT receptor by CRISPR-Cas9-based genome-wide...

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Bibliographic Details
Main Authors: Shihono Teruya, Yukihiro Hiramatsu, Keiji Nakamura, Aya Fukui-Miyazaki, Kentaro Tsukamoto, Noriko Shinoda, Daisuke Motooka, Shota Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Takashi Nishida, Fuminori Sugihara, Yusuke Maeda, Yasuhiko Horiguchi
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
pertussis
dermonecrotic toxin
receptor
encephalopathy
Microbiology
QR1-502
Online Access:https://doaj.org/article/9697f89d3b9948dc8e71e8e9ee0e55ae
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