Paroxetine overdose during pregnancy

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. In some epidemiological studies, slightly increased risks of major malformations and cardiac malformations have been reported following paroxetine exposure in the first trimester...

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Autores principales:	Selin Acar, Hilal Erol, Elif Keskin Arslan, Nusret Uysal, Barış Karadaş, Tijen Kaya Temiz, Yusuf Cem Kaplan
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	forensic sciences forensic toxicology paroxetine overdose teratogenicity case report Criminal law and procedure K5000-5582 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/969a65d8babe44bf871ce36da67f92af
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spelling	oai:doaj.org-article:969a65d8babe44bf871ce36da67f92af2021-12-01T14:40:59ZParoxetine overdose during pregnancy2096-17902471-141110.1080/20961790.2021.1938802https://doaj.org/article/969a65d8babe44bf871ce36da67f92af2021-07-01T00:00:00Zhttp://dx.doi.org/10.1080/20961790.2021.1938802https://doaj.org/toc/2096-1790https://doaj.org/toc/2471-1411Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. In some epidemiological studies, slightly increased risks of major malformations and cardiac malformations have been reported following paroxetine exposure in the first trimester of pregnancy. However, such findings have been inconsistent. There is only one report of any overdose of an SSRI during pregnancy, and that involved escitalopram. The aim of this case report was to describe the impact of a paroxetine overdose in the first trimester of pregnancy on the health of the foetus. A 21-year-old mother of one child who was pregnant with a second child was prescribed 20 mg/day paroxetine hydrochloride for the treatment of anxiety/depression. The patient ingested 15 or 16 20-mg tablets of paroxetine hydrochloride (300–320 mg) during the 5th week of pregnancy as a suicide attempt. Within 15 min of ingestion, she was admitted to hospital and treated for intoxication. No evidence of maternal SSRI intoxication was observed after treatment. The patient consulted our teratology information service for further risk assessment regarding possible major congenital malformations following the paroxetine overdose. We were unable to find previous reports of paroxetine overdose during pregnancy in the literature. The timely administration of the overdose treatment and the lack of maternal intoxication symptoms were considered positive for the foetal well-being, and the patient was referred for perinatology and psychiatry follow-ups. A healthy, 3 500-g male infant was born at 38 weeks’ gestation, and his development at the age of 2 years was normal. This is the first reported case of paroxetine overdose during pregnancy. Comprehensive studies are needed to evaluate pregnancy outcomes after SSRI overdose.Key Points There are no reported data on paroxetine overdose during pregnancy. The aim of this case report was to describe the impact of a maternal paroxetine overdose in the first trimester of pregnancy on the health of the foetus. No evidence of maternal SSRI intoxication was observed. No congenital malformations or developmental disorders were observed in the child at 2 years of age. Comprehensive studies are needed to evaluate pregnancy outcomes following SSRI overdose.Selin AcarHilal ErolElif Keskin ArslanNusret UysalBarış KaradaşTijen Kaya TemizYusuf Cem KaplanTaylor & Francis Grouparticleforensic sciencesforensic toxicologyparoxetineoverdoseteratogenicitycase reportCriminal law and procedureK5000-5582Public aspects of medicineRA1-1270ENForensic Sciences Research, Vol 6, Iss 3, Pp 237-239 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	forensic sciences forensic toxicology paroxetine overdose teratogenicity case report Criminal law and procedure K5000-5582 Public aspects of medicine RA1-1270
spellingShingle	forensic sciences forensic toxicology paroxetine overdose teratogenicity case report Criminal law and procedure K5000-5582 Public aspects of medicine RA1-1270 Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal Barış Karadaş Tijen Kaya Temiz Yusuf Cem Kaplan Paroxetine overdose during pregnancy
description	Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. In some epidemiological studies, slightly increased risks of major malformations and cardiac malformations have been reported following paroxetine exposure in the first trimester of pregnancy. However, such findings have been inconsistent. There is only one report of any overdose of an SSRI during pregnancy, and that involved escitalopram. The aim of this case report was to describe the impact of a paroxetine overdose in the first trimester of pregnancy on the health of the foetus. A 21-year-old mother of one child who was pregnant with a second child was prescribed 20 mg/day paroxetine hydrochloride for the treatment of anxiety/depression. The patient ingested 15 or 16 20-mg tablets of paroxetine hydrochloride (300–320 mg) during the 5th week of pregnancy as a suicide attempt. Within 15 min of ingestion, she was admitted to hospital and treated for intoxication. No evidence of maternal SSRI intoxication was observed after treatment. The patient consulted our teratology information service for further risk assessment regarding possible major congenital malformations following the paroxetine overdose. We were unable to find previous reports of paroxetine overdose during pregnancy in the literature. The timely administration of the overdose treatment and the lack of maternal intoxication symptoms were considered positive for the foetal well-being, and the patient was referred for perinatology and psychiatry follow-ups. A healthy, 3 500-g male infant was born at 38 weeks’ gestation, and his development at the age of 2 years was normal. This is the first reported case of paroxetine overdose during pregnancy. Comprehensive studies are needed to evaluate pregnancy outcomes after SSRI overdose.Key Points There are no reported data on paroxetine overdose during pregnancy. The aim of this case report was to describe the impact of a maternal paroxetine overdose in the first trimester of pregnancy on the health of the foetus. No evidence of maternal SSRI intoxication was observed. No congenital malformations or developmental disorders were observed in the child at 2 years of age. Comprehensive studies are needed to evaluate pregnancy outcomes following SSRI overdose.
format	article
author	Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal Barış Karadaş Tijen Kaya Temiz Yusuf Cem Kaplan
author_facet	Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal Barış Karadaş Tijen Kaya Temiz Yusuf Cem Kaplan
author_sort	Selin Acar
title	Paroxetine overdose during pregnancy
title_short	Paroxetine overdose during pregnancy
title_full	Paroxetine overdose during pregnancy
title_fullStr	Paroxetine overdose during pregnancy
title_full_unstemmed	Paroxetine overdose during pregnancy
title_sort	paroxetine overdose during pregnancy
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/969a65d8babe44bf871ce36da67f92af
work_keys_str_mv	AT selinacar paroxetineoverdoseduringpregnancy AT hilalerol paroxetineoverdoseduringpregnancy AT elifkeskinarslan paroxetineoverdoseduringpregnancy AT nusretuysal paroxetineoverdoseduringpregnancy AT barıskaradas paroxetineoverdoseduringpregnancy AT tijenkayatemiz paroxetineoverdoseduringpregnancy AT yusufcemkaplan paroxetineoverdoseduringpregnancy
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Paroxetine overdose during pregnancy

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