DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER

Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of...

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Autores principales: A. V. Zurochka, Yu. G. Suhovei, V. A. Zurochka, M. A. Dobrynina, E. G. Kostolomova, A. A. Kolobov, A. S. Simbirtsev
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Publicado: Sankt-Peterburg : NIIÈM imeni Pastera 2014
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Acceso en línea:https://doaj.org/article/969b0af213db4047944c39690a7d09c6
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spelling oai:doaj.org-article:969b0af213db4047944c39690a7d09c62021-11-22T07:09:45ZDOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER2220-76192313-739810.15789/2220-7619-2012-3-657-660https://doaj.org/article/969b0af213db4047944c39690a7d09c62014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/82https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of ZP-2 by action range and by rate of bactericidal activity in case of low concentration. Combined application of substance derived from supernatant of CD34+CD45-cells and synthetic peptide ZP-2 enhances significantly actions of each other. Probably, this effect is connected with various mechanisms of their influence on bacteria. The obtained facts indicate that synthetic peptide has not only immunostimulating action but it also promotes a direct antibacterial activity. These data support an idea that synthetic peptides have good perspectives in case of development new antibacterial drugs with unique characteristics.A. V. ZurochkaYu. G. SuhoveiV. A. ZurochkaM. A. DobryninaE. G. KostolomovaA. A. KolobovA. S. SimbirtsevSankt-Peterburg : NIIÈM imeni Pasteraarticlegm-csfpeptidesdefensinsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 3, Pp 657-660 (2014)
institution DOAJ
collection DOAJ
language RU
topic gm-csf
peptides
defensins
Infectious and parasitic diseases
RC109-216
spellingShingle gm-csf
peptides
defensins
Infectious and parasitic diseases
RC109-216
A. V. Zurochka
Yu. G. Suhovei
V. A. Zurochka
M. A. Dobrynina
E. G. Kostolomova
A. A. Kolobov
A. S. Simbirtsev
DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
description Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of ZP-2 by action range and by rate of bactericidal activity in case of low concentration. Combined application of substance derived from supernatant of CD34+CD45-cells and synthetic peptide ZP-2 enhances significantly actions of each other. Probably, this effect is connected with various mechanisms of their influence on bacteria. The obtained facts indicate that synthetic peptide has not only immunostimulating action but it also promotes a direct antibacterial activity. These data support an idea that synthetic peptides have good perspectives in case of development new antibacterial drugs with unique characteristics.
format article
author A. V. Zurochka
Yu. G. Suhovei
V. A. Zurochka
M. A. Dobrynina
E. G. Kostolomova
A. A. Kolobov
A. S. Simbirtsev
author_facet A. V. Zurochka
Yu. G. Suhovei
V. A. Zurochka
M. A. Dobrynina
E. G. Kostolomova
A. A. Kolobov
A. S. Simbirtsev
author_sort A. V. Zurochka
title DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_short DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_full DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_fullStr DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_full_unstemmed DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_sort dose-dependent effects of antibacterial activity of synthetic peptides isolated from gm-csf active center
publisher Sankt-Peterburg : NIIÈM imeni Pastera
publishDate 2014
url https://doaj.org/article/969b0af213db4047944c39690a7d09c6
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AT madobrynina dosedependenteffectsofantibacterialactivityofsyntheticpeptidesisolatedfromgmcsfactivecenter
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