DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER

Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of...

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Auteurs principaux:	A. V. Zurochka, Yu. G. Suhovei, V. A. Zurochka, M. A. Dobrynina, E. G. Kostolomova, A. A. Kolobov, A. S. Simbirtsev
Format:	article
Langue:	RU
Publié:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Sujets:	gm-csf peptides defensins Infectious and parasitic diseases RC109-216
Accès en ligne:	https://doaj.org/article/969b0af213db4047944c39690a7d09c6
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spelling	oai:doaj.org-article:969b0af213db4047944c39690a7d09c62021-11-22T07:09:45ZDOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER2220-76192313-739810.15789/2220-7619-2012-3-657-660https://doaj.org/article/969b0af213db4047944c39690a7d09c62014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/82https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of ZP-2 by action range and by rate of bactericidal activity in case of low concentration. Combined application of substance derived from supernatant of CD34+CD45-cells and synthetic peptide ZP-2 enhances significantly actions of each other. Probably, this effect is connected with various mechanisms of their influence on bacteria. The obtained facts indicate that synthetic peptide has not only immunostimulating action but it also promotes a direct antibacterial activity. These data support an idea that synthetic peptides have good perspectives in case of development new antibacterial drugs with unique characteristics.A. V. ZurochkaYu. G. SuhoveiV. A. ZurochkaM. A. DobryninaE. G. KostolomovaA. A. KolobovA. S. SimbirtsevSankt-Peterburg : NIIÈM imeni Pasteraarticlegm-csfpeptidesdefensinsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 3, Pp 657-660 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	gm-csf peptides defensins Infectious and parasitic diseases RC109-216
spellingShingle	gm-csf peptides defensins Infectious and parasitic diseases RC109-216 A. V. Zurochka Yu. G. Suhovei V. A. Zurochka M. A. Dobrynina E. G. Kostolomova A. A. Kolobov A. S. Simbirtsev DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
description	Abstract. Several endogenic and synthetic peptides were investigated in order to reveal their antibacterial activity. The study of dose-depended effects of antibacterial activity of the immunotropic peptide ZP-2, which is included in GM-CSF active center, shown significant antibacterial activity of ZP-2 by action range and by rate of bactericidal activity in case of low concentration. Combined application of substance derived from supernatant of CD34+CD45-cells and synthetic peptide ZP-2 enhances significantly actions of each other. Probably, this effect is connected with various mechanisms of their influence on bacteria. The obtained facts indicate that synthetic peptide has not only immunostimulating action but it also promotes a direct antibacterial activity. These data support an idea that synthetic peptides have good perspectives in case of development new antibacterial drugs with unique characteristics.
format	article
author	A. V. Zurochka Yu. G. Suhovei V. A. Zurochka M. A. Dobrynina E. G. Kostolomova A. A. Kolobov A. S. Simbirtsev
author_facet	A. V. Zurochka Yu. G. Suhovei V. A. Zurochka M. A. Dobrynina E. G. Kostolomova A. A. Kolobov A. S. Simbirtsev
author_sort	A. V. Zurochka
title	DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_short	DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_full	DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_fullStr	DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_full_unstemmed	DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER
title_sort	dose-dependent effects of antibacterial activity of synthetic peptides isolated from gm-csf active center
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/969b0af213db4047944c39690a7d09c6
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_version_	1718418054994460672

DOSE-DEPENDENT EFFECTS OF ANTIBACTERIAL ACTIVITY OF SYNTHETIC PEPTIDES ISOLATED FROM GM-CSF ACTIVE CENTER

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