Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane

Hung-Li Liu1, Shenghong A Dai1, Keng-Yen Fu2, Shan-hui Hsu21Department of Chemical Engineering, National Chung Hsing University, Taichung; 2Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of ChinaAbstract: Silver nanoparticles (AgNPs) are strong bac...

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Autores principales:	Hung-Li Liu, Shenghong A Dai, Keng-Yen Fu, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/969dd056a38245ea92165bc7de7a1ee3
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spelling	oai:doaj.org-article:969dd056a38245ea92165bc7de7a1ee32021-12-02T02:01:52ZAntibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane1176-91141178-2013https://doaj.org/article/969dd056a38245ea92165bc7de7a1ee32010-11-01T00:00:00Zhttp://www.dovepress.com/antibacterial-properties-of-silver-nanoparticles-in-three-different-si-a5705https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hung-Li Liu1, Shenghong A Dai1, Keng-Yen Fu2, Shan-hui Hsu21Department of Chemical Engineering, National Chung Hsing University, Taichung; 2Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of ChinaAbstract: Silver nanoparticles (AgNPs) are strong bactericidal agents but they are also cytotoxic. Embedding them in a polymer matrix may reduce their cytotoxic effect. In the present study, AgNPs in three average sizes were tested for their antibacterial activities and cytotoxicity. Nanocomposites from a new waterborne polyetherurethane (PEU) ionomer and AgNPs were prepared without the use of any crosslinker. It was observed that the antibacterial activity of AgNPs against Escherichia coli started at the effective concentration of 0.1&ndash;1 ppm, while that against Staphylococcus aureus started at higher concentrations of 1&ndash;10 ppm. Cytotoxicity of AgNPs was observed at the concentration of 10 ppm. AgNPs with smaller average size showed greater antibacterial activity as well as cytotoxicity. The PEU synthesized in this study showed high tensile strength, and the addition of AgNPs at all sizes further increased its thermal stability. The delicate surface features of nanophases, however, were only observed in nanocomposites with either small- or medium-sized AgNPs. PEU-Ag nanocomposites had a strong bacteriostatic effect on the growth of E. coli and S. aureus. The proliferation of endothelial cells on PEU-Ag nanocomposites was enhanced, whereas the platelet adhesion was reduced. The expression of endothelial nitric oxide synthase gene was upregulated on PEU-Ag containing small-sized AgNPs (30 ppm) or medium-sized AgNPs (60 ppm). This effect was not as remarkable in nanocomposites from large-sized AgNPs. Overall, nanocomposites from the PEU and 60 ppm of the medium-sized (5 nm) AgNPs showed the best biocompatibility and antibacterial activity. Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs.Keywords: silver nanoparticles, polyurethane, antibacterial activity, biocompatibility Hung-Li LiuShenghong A DaiKeng-Yen Fuet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 1017-1028 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Hung-Li Liu Shenghong A Dai Keng-Yen Fu et al Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
description	Hung-Li Liu1, Shenghong A Dai1, Keng-Yen Fu2, Shan-hui Hsu21Department of Chemical Engineering, National Chung Hsing University, Taichung; 2Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of ChinaAbstract: Silver nanoparticles (AgNPs) are strong bactericidal agents but they are also cytotoxic. Embedding them in a polymer matrix may reduce their cytotoxic effect. In the present study, AgNPs in three average sizes were tested for their antibacterial activities and cytotoxicity. Nanocomposites from a new waterborne polyetherurethane (PEU) ionomer and AgNPs were prepared without the use of any crosslinker. It was observed that the antibacterial activity of AgNPs against Escherichia coli started at the effective concentration of 0.1&ndash;1 ppm, while that against Staphylococcus aureus started at higher concentrations of 1&ndash;10 ppm. Cytotoxicity of AgNPs was observed at the concentration of 10 ppm. AgNPs with smaller average size showed greater antibacterial activity as well as cytotoxicity. The PEU synthesized in this study showed high tensile strength, and the addition of AgNPs at all sizes further increased its thermal stability. The delicate surface features of nanophases, however, were only observed in nanocomposites with either small- or medium-sized AgNPs. PEU-Ag nanocomposites had a strong bacteriostatic effect on the growth of E. coli and S. aureus. The proliferation of endothelial cells on PEU-Ag nanocomposites was enhanced, whereas the platelet adhesion was reduced. The expression of endothelial nitric oxide synthase gene was upregulated on PEU-Ag containing small-sized AgNPs (30 ppm) or medium-sized AgNPs (60 ppm). This effect was not as remarkable in nanocomposites from large-sized AgNPs. Overall, nanocomposites from the PEU and 60 ppm of the medium-sized (5 nm) AgNPs showed the best biocompatibility and antibacterial activity. Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs.Keywords: silver nanoparticles, polyurethane, antibacterial activity, biocompatibility
format	article
author	Hung-Li Liu Shenghong A Dai Keng-Yen Fu et al
author_facet	Hung-Li Liu Shenghong A Dai Keng-Yen Fu et al
author_sort	Hung-Li Liu
title	Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
title_short	Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
title_full	Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
title_fullStr	Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
title_full_unstemmed	Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
title_sort	antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/969dd056a38245ea92165bc7de7a1ee3
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Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane

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