Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression

Abstract Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more frequent in diffuse large B cell lymphoma (DLBCL) that l...

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Autores principales:	Marina Kazantseva, Noelyn A. Hung, Sunali Mehta, Imogen Roth, Ramona Eiholzer, Alison M. Rich, Benedict Seo, Margaret A. Baird, Antony W. Braithwaite, Tania L. Slatter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/969e6784a7154eea9c67d1c473e2032f
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spelling	oai:doaj.org-article:969e6784a7154eea9c67d1c473e2032f2021-12-02T16:06:18ZTumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression10.1038/s41598-017-01800-62045-2322https://doaj.org/article/969e6784a7154eea9c67d1c473e2032f2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01800-6https://doaj.org/toc/2045-2322Abstract Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more frequent in diffuse large B cell lymphoma (DLBCL) that lacked the B cell lineage marker CD19. Sixteen CD19 negative and 78 CD19 positive DLBCL were sequenced for TP53 mutations. Twenty nine tumors had TP53 mutations and were associated with poorer survival. Mutant TP53 was more frequent in CD19 negative lymphomas (81% versus 21%, p < 0.0001). Analysis of other B cell markers revealed a lack of paired box 5 (PAX5) in CD19 positive lymphomas with mutant TP53 (50%), which was more frequent compared to tumors with wild-type TP53 (15%, p = 0.002). In summary, DLBCL lacking CD19 or PAX5 expression were more likely to have mutant TP53, suggesting irregular B cell marker phenotypes are associated with TP53 mutation.Marina KazantsevaNoelyn A. HungSunali MehtaImogen RothRamona EiholzerAlison M. RichBenedict SeoMargaret A. BairdAntony W. BraithwaiteTania L. SlatterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marina Kazantseva Noelyn A. Hung Sunali Mehta Imogen Roth Ramona Eiholzer Alison M. Rich Benedict Seo Margaret A. Baird Antony W. Braithwaite Tania L. Slatter Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
description	Abstract Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more frequent in diffuse large B cell lymphoma (DLBCL) that lacked the B cell lineage marker CD19. Sixteen CD19 negative and 78 CD19 positive DLBCL were sequenced for TP53 mutations. Twenty nine tumors had TP53 mutations and were associated with poorer survival. Mutant TP53 was more frequent in CD19 negative lymphomas (81% versus 21%, p < 0.0001). Analysis of other B cell markers revealed a lack of paired box 5 (PAX5) in CD19 positive lymphomas with mutant TP53 (50%), which was more frequent compared to tumors with wild-type TP53 (15%, p = 0.002). In summary, DLBCL lacking CD19 or PAX5 expression were more likely to have mutant TP53, suggesting irregular B cell marker phenotypes are associated with TP53 mutation.
format	article
author	Marina Kazantseva Noelyn A. Hung Sunali Mehta Imogen Roth Ramona Eiholzer Alison M. Rich Benedict Seo Margaret A. Baird Antony W. Braithwaite Tania L. Slatter
author_facet	Marina Kazantseva Noelyn A. Hung Sunali Mehta Imogen Roth Ramona Eiholzer Alison M. Rich Benedict Seo Margaret A. Baird Antony W. Braithwaite Tania L. Slatter
author_sort	Marina Kazantseva
title	Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
title_short	Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
title_full	Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
title_fullStr	Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
title_full_unstemmed	Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression
title_sort	tumor protein 53 mutations are enriched in diffuse large b-cell lymphoma with irregular cd19 marker expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/969e6784a7154eea9c67d1c473e2032f
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Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression

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