Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Peripheral T cell lymphoma (PTCL) not otherwise specified (NOS) is a subgroup of PTCL, which has no distinctive features and is poorly characterized at the genetic level. Here, the authors identify two fusion transcripts that activate T cell receptor complex signalling and confer therapeutic vulnera...

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Autores principales: Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/969eed6176e84cfbb86762c9aa0218ee
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spelling oai:doaj.org-article:969eed6176e84cfbb86762c9aa0218ee2021-12-02T17:23:48ZFusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified10.1038/s41467-021-24037-42041-1723https://doaj.org/article/969eed6176e84cfbb86762c9aa0218ee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24037-4https://doaj.org/toc/2041-1723Peripheral T cell lymphoma (PTCL) not otherwise specified (NOS) is a subgroup of PTCL, which has no distinctive features and is poorly characterized at the genetic level. Here, the authors identify two fusion transcripts that activate T cell receptor complex signalling and confer therapeutic vulnerability in PTCL-NOS.Koen DebackereLukas MarcelisSofie DemeyerMarlies Vanden BemptNicole MentensOlga GielenKris JacobsMichael BrouxGregor VerhoefLucienne MichauxCarlos GrauxIwona WlodarskaPhilippe GaulardLaurence de LevalThomas TousseynJan CoolsDaan DierickxNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Koen Debackere
Lukas Marcelis
Sofie Demeyer
Marlies Vanden Bempt
Nicole Mentens
Olga Gielen
Kris Jacobs
Michael Broux
Gregor Verhoef
Lucienne Michaux
Carlos Graux
Iwona Wlodarska
Philippe Gaulard
Laurence de Leval
Thomas Tousseyn
Jan Cools
Daan Dierickx
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
description Peripheral T cell lymphoma (PTCL) not otherwise specified (NOS) is a subgroup of PTCL, which has no distinctive features and is poorly characterized at the genetic level. Here, the authors identify two fusion transcripts that activate T cell receptor complex signalling and confer therapeutic vulnerability in PTCL-NOS.
format article
author Koen Debackere
Lukas Marcelis
Sofie Demeyer
Marlies Vanden Bempt
Nicole Mentens
Olga Gielen
Kris Jacobs
Michael Broux
Gregor Verhoef
Lucienne Michaux
Carlos Graux
Iwona Wlodarska
Philippe Gaulard
Laurence de Leval
Thomas Tousseyn
Jan Cools
Daan Dierickx
author_facet Koen Debackere
Lukas Marcelis
Sofie Demeyer
Marlies Vanden Bempt
Nicole Mentens
Olga Gielen
Kris Jacobs
Michael Broux
Gregor Verhoef
Lucienne Michaux
Carlos Graux
Iwona Wlodarska
Philippe Gaulard
Laurence de Leval
Thomas Tousseyn
Jan Cools
Daan Dierickx
author_sort Koen Debackere
title Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
title_short Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
title_full Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
title_fullStr Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
title_full_unstemmed Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
title_sort fusion transcripts fyn-traf3ip2 and khdrbs1-lck hijack t cell receptor signaling in peripheral t-cell lymphoma, not otherwise specified
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/969eed6176e84cfbb86762c9aa0218ee
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