Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer
Bernadette Biondi, Melania Pulcrano, Loredana Pagano, Gaetano LombardiDepartment of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, ItalyAbstract: Various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulat...
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Dove Medical Press
2008
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oai:doaj.org-article:96ab15e2218549b3bdfa6a869b3626442021-12-02T05:38:51ZAdjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer1177-54751177-5491https://doaj.org/article/96ab15e2218549b3bdfa6a869b3626442008-12-01T00:00:00Zhttp://www.dovepress.com/adjuvant-treatment-with-thyrotropin-alpha-for-remnant-ablation-in-thyr-a2652https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Bernadette Biondi, Melania Pulcrano, Loredana Pagano, Gaetano LombardiDepartment of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, ItalyAbstract: Various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhTSH) for radioiodine remnant ablation. On this basis, rhTSH was approved in Europe for the radioiodine ablation of low-risk differentiated thyroid cancer (DTC) during thyroid hormone therapy with L-thyroxine (L-T4). Moreover, in December 2007, the US Federal Drug Administration approved the use of rhTSH for adjuvant treatment with radioiodine in patients with DTC without evidence of metastatic thyroid cancer. Quality of life was found to be better with rhTSH preparation than with L-thyroxine withdrawal, thereby resulting in benefits for society as a whole. Furthermore, rhTSH for radioiodine remnant ablation results in a longer effective radioiodine half-life within remnant thyroid tissue and a lower specific absorbed dose in the blood and exposure of bone marrow to X-rays. More studies are required to establish the amount of radioiodine to be administered especially in high-risk patients. Keywords: thyroid cancer, thyrotropin, radioiodine (131I) remnant ablation (RRA), quality of life, ray exposure Bernadette BiondiMelania PulcranoLoredana PaganoGaetano LombardiDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2009, Iss default, Pp 9-13 (2008) |
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Medicine (General) R5-920 Bernadette Biondi Melania Pulcrano Loredana Pagano Gaetano Lombardi Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
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Bernadette Biondi, Melania Pulcrano, Loredana Pagano, Gaetano LombardiDepartment of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, ItalyAbstract: Various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhTSH) for radioiodine remnant ablation. On this basis, rhTSH was approved in Europe for the radioiodine ablation of low-risk differentiated thyroid cancer (DTC) during thyroid hormone therapy with L-thyroxine (L-T4). Moreover, in December 2007, the US Federal Drug Administration approved the use of rhTSH for adjuvant treatment with radioiodine in patients with DTC without evidence of metastatic thyroid cancer. Quality of life was found to be better with rhTSH preparation than with L-thyroxine withdrawal, thereby resulting in benefits for society as a whole. Furthermore, rhTSH for radioiodine remnant ablation results in a longer effective radioiodine half-life within remnant thyroid tissue and a lower specific absorbed dose in the blood and exposure of bone marrow to X-rays. More studies are required to establish the amount of radioiodine to be administered especially in high-risk patients. Keywords: thyroid cancer, thyrotropin, radioiodine (131I) remnant ablation (RRA), quality of life, ray exposure |
format |
article |
author |
Bernadette Biondi Melania Pulcrano Loredana Pagano Gaetano Lombardi |
author_facet |
Bernadette Biondi Melania Pulcrano Loredana Pagano Gaetano Lombardi |
author_sort |
Bernadette Biondi |
title |
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
title_short |
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
title_full |
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
title_fullStr |
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
title_full_unstemmed |
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
title_sort |
adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer |
publisher |
Dove Medical Press |
publishDate |
2008 |
url |
https://doaj.org/article/96ab15e2218549b3bdfa6a869b362644 |
work_keys_str_mv |
AT bernadettebiondi adjuvanttreatmentwiththyrotropinalphaforremnantablationinthyroidcancer AT melaniapulcrano adjuvanttreatmentwiththyrotropinalphaforremnantablationinthyroidcancer AT loredanapagano adjuvanttreatmentwiththyrotropinalphaforremnantablationinthyroidcancer AT gaetanolombardi adjuvanttreatmentwiththyrotropinalphaforremnantablationinthyroidcancer |
_version_ |
1718400311143432192 |