Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases

Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.

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Autores principales:	Nannan Su, Alicia K. Byrd, Sakshibeedu R. Bharath, Olivia Yang, Yu Jia, Xuhua Tang, Taekjip Ha, Kevin D. Raney, Haiwei Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96ab66ada22747c98c3f99197371f70c
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spelling	oai:doaj.org-article:96ab66ada22747c98c3f99197371f70c2021-12-02T15:35:30ZStructural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases10.1038/s41467-019-13414-92041-1723https://doaj.org/article/96ab66ada22747c98c3f99197371f70c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13414-9https://doaj.org/toc/2041-1723Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.Nannan SuAlicia K. ByrdSakshibeedu R. BharathOlivia YangYu JiaXuhua TangTaekjip HaKevin D. RaneyHaiwei SongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nannan Su Alicia K. Byrd Sakshibeedu R. Bharath Olivia Yang Yu Jia Xuhua Tang Taekjip Ha Kevin D. Raney Haiwei Song Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
description	Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.
format	article
author	Nannan Su Alicia K. Byrd Sakshibeedu R. Bharath Olivia Yang Yu Jia Xuhua Tang Taekjip Ha Kevin D. Raney Haiwei Song
author_facet	Nannan Su Alicia K. Byrd Sakshibeedu R. Bharath Olivia Yang Yu Jia Xuhua Tang Taekjip Ha Kevin D. Raney Haiwei Song
author_sort	Nannan Su
title	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
title_short	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
title_full	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
title_fullStr	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
title_full_unstemmed	Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
title_sort	structural basis for dna unwinding at forked dsdna by two coordinating pif1 helicases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/96ab66ada22747c98c3f99197371f70c
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Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases

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