CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

We studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,...

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Autores principales:	E. G. Lobanova, E. P. Kalinina, Yu. K. Denisenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	chronic obstructive pulmonary disease t helpers th1 th17 type cytokines immunе regulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/96ad2cdfeab54106a5ff87be5e56ca56
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spelling	oai:doaj.org-article:96ad2cdfeab54106a5ff87be5e56ca562021-11-18T08:03:45ZCYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE1563-06252313-741X10.15789/1563-0625-2016-3-287-290https://doaj.org/article/96ad2cdfeab54106a5ff87be5e56ca562016-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1042https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,IL-17A, IL-21, IFNγ, TGF-β1. We found that the shift in balance of pro- and anti-inflammatory cytokines is typical to both Th1 and Th17 immune response types in COPD of different severity. The variety of immune response types was achieved due to activation of different effector cells. I.e., the Th1 response was associated with macrophage activation and IFNγ induction, whereas domination of Th17 response was accompanied by activation of neutrophils, and increased synthesis of IL-17, IL-21. The Th17 type of immune response was shown to prevail in severe COPD. Thus, the certain types of immune disorders in COPD presume application of combined therapy including immunocorrective drugs which are able to suppress inflammation and correct the cytokine imbalances.E. G. LobanovaE. P. KalininaYu. K. DenisenkoSPb RAACIarticlechronic obstructive pulmonary diseaset helpersth1th17 typecytokinesimmunе regulationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 3, Pp 287-290 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease t helpers th1 th17 type cytokines immunе regulation Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease t helpers th1 th17 type cytokines immunе regulation Immunologic diseases. Allergy RC581-607 E. G. Lobanova E. P. Kalinina Yu. K. Denisenko CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
description	We studied cytokine profiles relevant to the Th1 and Th17 modes of immune response in 116 patients with mild, moderate and severe chronic obstructive pulmonary disease (COPD). Relative contents of Th1- and Th17-type lymphocytes were evaluated by serum levels of specific cytokines: TNFα, IL-6, IL-10,IL-17A, IL-21, IFNγ, TGF-β1. We found that the shift in balance of pro- and anti-inflammatory cytokines is typical to both Th1 and Th17 immune response types in COPD of different severity. The variety of immune response types was achieved due to activation of different effector cells. I.e., the Th1 response was associated with macrophage activation and IFNγ induction, whereas domination of Th17 response was accompanied by activation of neutrophils, and increased synthesis of IL-17, IL-21. The Th17 type of immune response was shown to prevail in severe COPD. Thus, the certain types of immune disorders in COPD presume application of combined therapy including immunocorrective drugs which are able to suppress inflammation and correct the cytokine imbalances.
format	article
author	E. G. Lobanova E. P. Kalinina Yu. K. Denisenko
author_facet	E. G. Lobanova E. P. Kalinina Yu. K. Denisenko
author_sort	E. G. Lobanova
title	CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_short	CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full	CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_fullStr	CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full_unstemmed	CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_sort	cytokine contents in th1- and th17-type lymphocytes in chronic obstructive pulmonary disease
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/96ad2cdfeab54106a5ff87be5e56ca56
work_keys_str_mv	AT eglobanova cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease AT epkalinina cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease AT yukdenisenko cytokinecontentsinth1andth17typelymphocytesinchronicobstructivepulmonarydisease
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CYTOKINE CONTENTS IN Th1- AND Th17-TYPE LYMPHOCYTES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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