Association of infertility with premature mortality among US women: Prospective cohort study

Summary: Background: Infertility has been associated with common chronic non-communicable diseases. However, the association of infertility with long-term mortality is unclear. Methods: We followed 101,777 women aged 25–42 years at enrollment between 1989 and 2017. Biennial questionnaires updated p...

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Autores principales:	Yi-Xin Wang, Leslie V. Farland, Siwen Wang, Audrey J. Gaskins, Liang Wang, Janet W. Rich-Edwards, Rulla Tamimi, Stacey A. Missmer, Jorge E. Chavarro
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Infertility, Premature mortality, Women, Public health Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/96ae12b72b5348cf94b34485644c4ec4
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spelling	oai:doaj.org-article:96ae12b72b5348cf94b34485644c4ec42021-12-02T05:04:43ZAssociation of infertility with premature mortality among US women: Prospective cohort study2667-193X10.1016/j.lana.2021.100122https://doaj.org/article/96ae12b72b5348cf94b34485644c4ec42022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667193X21001186https://doaj.org/toc/2667-193XSummary: Background: Infertility has been associated with common chronic non-communicable diseases. However, the association of infertility with long-term mortality is unclear. Methods: We followed 101,777 women aged 25–42 years at enrollment between 1989 and 2017. Biennial questionnaires updated participants’ infertility status and underlying reasons for infertility throughout their reproductive lifespan. Hazard ratios (HRs) for the associations of infertility with the risk of premature mortality (death before age 70 years) were estimated using Cox proportional hazards models. Findings: During 28 years of follow-up, 2174 women died before age 70 years. Infertility was associated with an HR of 1.26 (95% confidence interval: 1.15 to 1.38) for premature death. This relation was largely driven by deaths from cancer (HR = 1.22, 1.08 to 1.39) and was stronger among women reporting infertility at a younger age (HR = 1.35, 1.19 to 1.52 for age ≤ 25 years; 1.23, 1.10 to 1.38 for age 26–30 years; and 1.10, 0.91 to 1.32 for age > 30 years, compared to no infertility). The premature mortality risk was also higher for women who didn't become pregnant after their first report of infertility (HR = 1.39, 1.25 to 1.54) than among women who reported at least one pregnancy after infertility (HR = 1.12, 1.00 to 1.26). When contributing diagnoses of infertility were evaluated, a greater risk of all-cause mortality was associated with infertility due to ovulatory disorders (HR = 1.28, 1.09 to 1.51) and endometriosis (HR = 1.50, 1.22 to 1.83). Interpretation: Infertility may be associated with a greater risk of premature mortality, particularly cancer mortality. Funding: The National Institutes of Health grants.Yi-Xin WangLeslie V. FarlandSiwen WangAudrey J. GaskinsLiang WangJanet W. Rich-EdwardsRulla TamimiStacey A. MissmerJorge E. ChavarroElsevierarticleInfertility, Premature mortality, Women, Public healthPublic aspects of medicineRA1-1270ENThe Lancet Regional Health. Americas, Vol 7, Iss , Pp 100122- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infertility, Premature mortality, Women, Public health Public aspects of medicine RA1-1270
spellingShingle	Infertility, Premature mortality, Women, Public health Public aspects of medicine RA1-1270 Yi-Xin Wang Leslie V. Farland Siwen Wang Audrey J. Gaskins Liang Wang Janet W. Rich-Edwards Rulla Tamimi Stacey A. Missmer Jorge E. Chavarro Association of infertility with premature mortality among US women: Prospective cohort study
description	Summary: Background: Infertility has been associated with common chronic non-communicable diseases. However, the association of infertility with long-term mortality is unclear. Methods: We followed 101,777 women aged 25–42 years at enrollment between 1989 and 2017. Biennial questionnaires updated participants’ infertility status and underlying reasons for infertility throughout their reproductive lifespan. Hazard ratios (HRs) for the associations of infertility with the risk of premature mortality (death before age 70 years) were estimated using Cox proportional hazards models. Findings: During 28 years of follow-up, 2174 women died before age 70 years. Infertility was associated with an HR of 1.26 (95% confidence interval: 1.15 to 1.38) for premature death. This relation was largely driven by deaths from cancer (HR = 1.22, 1.08 to 1.39) and was stronger among women reporting infertility at a younger age (HR = 1.35, 1.19 to 1.52 for age ≤ 25 years; 1.23, 1.10 to 1.38 for age 26–30 years; and 1.10, 0.91 to 1.32 for age > 30 years, compared to no infertility). The premature mortality risk was also higher for women who didn't become pregnant after their first report of infertility (HR = 1.39, 1.25 to 1.54) than among women who reported at least one pregnancy after infertility (HR = 1.12, 1.00 to 1.26). When contributing diagnoses of infertility were evaluated, a greater risk of all-cause mortality was associated with infertility due to ovulatory disorders (HR = 1.28, 1.09 to 1.51) and endometriosis (HR = 1.50, 1.22 to 1.83). Interpretation: Infertility may be associated with a greater risk of premature mortality, particularly cancer mortality. Funding: The National Institutes of Health grants.
format	article
author	Yi-Xin Wang Leslie V. Farland Siwen Wang Audrey J. Gaskins Liang Wang Janet W. Rich-Edwards Rulla Tamimi Stacey A. Missmer Jorge E. Chavarro
author_facet	Yi-Xin Wang Leslie V. Farland Siwen Wang Audrey J. Gaskins Liang Wang Janet W. Rich-Edwards Rulla Tamimi Stacey A. Missmer Jorge E. Chavarro
author_sort	Yi-Xin Wang
title	Association of infertility with premature mortality among US women: Prospective cohort study
title_short	Association of infertility with premature mortality among US women: Prospective cohort study
title_full	Association of infertility with premature mortality among US women: Prospective cohort study
title_fullStr	Association of infertility with premature mortality among US women: Prospective cohort study
title_full_unstemmed	Association of infertility with premature mortality among US women: Prospective cohort study
title_sort	association of infertility with premature mortality among us women: prospective cohort study
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/96ae12b72b5348cf94b34485644c4ec4
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Association of infertility with premature mortality among US women: Prospective cohort study

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