<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee

Dominance hierarchies are ubiquitous in invertebrates and vertebrates, but little is known on how genes influence dominance rank. Our gaps in knowledge are specifically significant concerning female hierarchies, particularly in insects. To start filling these gaps, we studied the social bumble bee &...

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Auteurs principaux:	Atul Pandey, Guy Bloch
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	<i>Krüppel-homologue 1</i> juvenile hormone vitellogenin RNA interference nanoparticles reproduction Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/96b4796fa2db4fb29d78816297c34e06
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id	oai:doaj.org-article:96b4796fa2db4fb29d78816297c34e06
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spelling	oai:doaj.org-article:96b4796fa2db4fb29d78816297c34e062021-11-25T16:47:49Z<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee10.3390/biology101111882079-7737https://doaj.org/article/96b4796fa2db4fb29d78816297c34e062021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1188https://doaj.org/toc/2079-7737Dominance hierarchies are ubiquitous in invertebrates and vertebrates, but little is known on how genes influence dominance rank. Our gaps in knowledge are specifically significant concerning female hierarchies, particularly in insects. To start filling these gaps, we studied the social bumble bee <i>Bombus terrestris</i>, in which social hierarchies among females are common and functionally significant. Dominance rank in this bee is influenced by multiple factors, including juvenile hormone (JH) that is a major gonadotropin in this species. We tested the hypothesis that the JH responsive transcription factor <i>Krüppel homologue 1</i> (<i>Kr-h1</i>) mediates hormonal influences on dominance behavior. We first developed and validated a perfluorocarbon nanoparticles-based RNA interference protocol for knocking down <i>Kr-h1</i> expression. We then used this procedure to show that <i>Kr-h1</i> mediates the influence of JH, not only on oogenesis and wax production, but also on aggression and dominance rank. To the best of our knowledge, this is the first study causally linking a gene to dominance rank in social insects, and one of only a few such studies on insects or on female hierarchies. These findings are important for determining whether there are general molecular principles governing dominance rank across gender and taxa.Atul PandeyGuy BlochMDPI AGarticle<i>Krüppel-homologue 1</i>juvenile hormonevitellogeninRNA interferencenanoparticlesreproductionBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1188, p 1188 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Krüppel-homologue 1</i> juvenile hormone vitellogenin RNA interference nanoparticles reproduction Biology (General) QH301-705.5
spellingShingle	<i>Krüppel-homologue 1</i> juvenile hormone vitellogenin RNA interference nanoparticles reproduction Biology (General) QH301-705.5 Atul Pandey Guy Bloch <i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
description	Dominance hierarchies are ubiquitous in invertebrates and vertebrates, but little is known on how genes influence dominance rank. Our gaps in knowledge are specifically significant concerning female hierarchies, particularly in insects. To start filling these gaps, we studied the social bumble bee <i>Bombus terrestris</i>, in which social hierarchies among females are common and functionally significant. Dominance rank in this bee is influenced by multiple factors, including juvenile hormone (JH) that is a major gonadotropin in this species. We tested the hypothesis that the JH responsive transcription factor <i>Krüppel homologue 1</i> (<i>Kr-h1</i>) mediates hormonal influences on dominance behavior. We first developed and validated a perfluorocarbon nanoparticles-based RNA interference protocol for knocking down <i>Kr-h1</i> expression. We then used this procedure to show that <i>Kr-h1</i> mediates the influence of JH, not only on oogenesis and wax production, but also on aggression and dominance rank. To the best of our knowledge, this is the first study causally linking a gene to dominance rank in social insects, and one of only a few such studies on insects or on female hierarchies. These findings are important for determining whether there are general molecular principles governing dominance rank across gender and taxa.
format	article
author	Atul Pandey Guy Bloch
author_facet	Atul Pandey Guy Bloch
author_sort	Atul Pandey
title	<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
title_short	<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
title_full	<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
title_fullStr	<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
title_full_unstemmed	<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee
title_sort	<i>krüppel-homologue 1</i> mediates hormonally regulated dominance rank in a social bee
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/96b4796fa2db4fb29d78816297c34e06
work_keys_str_mv	AT atulpandey ikruppelhomologue1imediateshormonallyregulateddominancerankinasocialbee AT guybloch ikruppelhomologue1imediateshormonallyregulateddominancerankinasocialbee
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<i>Krüppel-homologue 1</i> Mediates Hormonally Regulated Dominance Rank in a Social Bee

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