Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins

Ping Lv,* Yaofu Zheng,* Jun Huang, Junsong Ke, Hongyu Zhang Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun HuangDepartment of Cardiology,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lv P, Zheng Y, Huang J, Ke J, Zhang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	apolipoprotein e polymorphism coronary heart disease ischemic stroke statins Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/96b540f64377426f91ab7551fbe69fa6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96b540f64377426f91ab7551fbe69fa6
record_format	dspace
spelling	oai:doaj.org-article:96b540f64377426f91ab7551fbe69fa62021-12-02T12:09:10ZAssociation of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins1178-2021https://doaj.org/article/96b540f64377426f91ab7551fbe69fa62020-10-01T00:00:00Zhttps://www.dovepress.com/association-of-apolipoprotein-e-gene-polymorphism-with-ischemic-stroke-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ping Lv,* Yaofu Zheng,* Jun Huang, Junsong Ke, Hongyu Zhang Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun HuangDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng St, Nanchang, Jiangxi 330006, People’s Republic of ChinaTel +86-138 70057352Fax +86-791-88694579Email junhuang918@163.comObjective: To study the association of apolipoprotein E(APOE) gene polymorphism with ischemic stroke (IS) in coronary heart disease (CHD) patients treated with medium-intensity statins.Methods: The retrospective study was performed on 662 samples including 169 CHD subjects complicated with IS, 296 subjects with CHD, and 197 control subjects. The APOE gene was obtained from case files. Univariable and multivariable logistic regression analyses were utilized to recognize the possible risks of CHD and IS.Results: The frequency of ϵ3-ϵ4 genotype was increased in the CHD group (p=0.013) and CHD-IS group (p=0.001), the frequency of ϵ4 allele was also increased in the CHD group (p=0.047) and the CHD-IS group (p=0.009) compared with control group. ϵ3-ϵ4 genotype was the independent risk for CHD and CHD-IS after adjusting for traditional risk factors with adjusted odds ratio (AOR) 2.210, 95%CI: 1.263– 3.867, p=0.005) and (AOR 2.794, 95%CI: 1.539– 5.072, p=0.002). The ϵ4 allele was also significantly associated with CHD (AOR 2.126, 95%CI: 1.265– 3.575,=0.004) and CHD-IS (AOR 2.740, 95%CI: 1.569– 4.784, p=0.001).Conclusion: These results demonstrated that ϵ4 allele influenced the development of CHD with or without IS, especially for the genotype of ϵ3-ϵ4. CHD patients carrying the ϵ3-ϵ4 genotype and the ϵ4 allele were significantly associated with the incidence of IS, even if medium-intensity statins had been used.Keywords: apolipoprotein E, polymorphism, coronary heart disease, ischemic stroke, statinsLv PZheng YHuang JKe JZhang HDove Medical Pressarticleapolipoprotein epolymorphismcoronary heart diseaseischemic strokestatinsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2459-2466 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	apolipoprotein e polymorphism coronary heart disease ischemic stroke statins Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	apolipoprotein e polymorphism coronary heart disease ischemic stroke statins Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lv P Zheng Y Huang J Ke J Zhang H Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
description	Ping Lv,* Yaofu Zheng,* Jun Huang, Junsong Ke, Hongyu Zhang Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun HuangDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng St, Nanchang, Jiangxi 330006, People’s Republic of ChinaTel +86-138 70057352Fax +86-791-88694579Email junhuang918@163.comObjective: To study the association of apolipoprotein E(APOE) gene polymorphism with ischemic stroke (IS) in coronary heart disease (CHD) patients treated with medium-intensity statins.Methods: The retrospective study was performed on 662 samples including 169 CHD subjects complicated with IS, 296 subjects with CHD, and 197 control subjects. The APOE gene was obtained from case files. Univariable and multivariable logistic regression analyses were utilized to recognize the possible risks of CHD and IS.Results: The frequency of ϵ3-ϵ4 genotype was increased in the CHD group (p=0.013) and CHD-IS group (p=0.001), the frequency of ϵ4 allele was also increased in the CHD group (p=0.047) and the CHD-IS group (p=0.009) compared with control group. ϵ3-ϵ4 genotype was the independent risk for CHD and CHD-IS after adjusting for traditional risk factors with adjusted odds ratio (AOR) 2.210, 95%CI: 1.263– 3.867, p=0.005) and (AOR 2.794, 95%CI: 1.539– 5.072, p=0.002). The ϵ4 allele was also significantly associated with CHD (AOR 2.126, 95%CI: 1.265– 3.575,=0.004) and CHD-IS (AOR 2.740, 95%CI: 1.569– 4.784, p=0.001).Conclusion: These results demonstrated that ϵ4 allele influenced the development of CHD with or without IS, especially for the genotype of ϵ3-ϵ4. CHD patients carrying the ϵ3-ϵ4 genotype and the ϵ4 allele were significantly associated with the incidence of IS, even if medium-intensity statins had been used.Keywords: apolipoprotein E, polymorphism, coronary heart disease, ischemic stroke, statins
format	article
author	Lv P Zheng Y Huang J Ke J Zhang H
author_facet	Lv P Zheng Y Huang J Ke J Zhang H
author_sort	Lv P
title	Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
title_short	Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
title_full	Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
title_fullStr	Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
title_full_unstemmed	Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins
title_sort	association of apolipoprotein e gene polymorphism with ischemic stroke in coronary heart disease patients treated with medium-intensity statins
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/96b540f64377426f91ab7551fbe69fa6
work_keys_str_mv	AT lvp associationofapolipoproteinegenepolymorphismwithischemicstrokeincoronaryheartdiseasepatientstreatedwithmediumintensitystatins AT zhengy associationofapolipoproteinegenepolymorphismwithischemicstrokeincoronaryheartdiseasepatientstreatedwithmediumintensitystatins AT huangj associationofapolipoproteinegenepolymorphismwithischemicstrokeincoronaryheartdiseasepatientstreatedwithmediumintensitystatins AT kej associationofapolipoproteinegenepolymorphismwithischemicstrokeincoronaryheartdiseasepatientstreatedwithmediumintensitystatins AT zhangh associationofapolipoproteinegenepolymorphismwithischemicstrokeincoronaryheartdiseasepatientstreatedwithmediumintensitystatins
_version_	1718394703538290688

Association of Apolipoprotein E Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins

Ejemplares similares