Smoking results in accumulation of ectopic fat in the liver

Ayako Kato,1 Yuanying Li,1 Atsuhiko Ota,1 Hisao Naito,1 Hiroya Yamada,2 Takashi Nihashi,3 Yo Hotta,4 Chifa Chiang,5 Yoshihisa Hirakawa,5 Atsuko Aoyama,5,6 Koji Tamakoshi,7 Hiroshi Yatsuya1,51Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2De...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	intrahepatic fat cigarette smoking adiponectin triglycerides cross-sectional study. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/96ba33f94cd24ba9846730d9ff7c36cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96ba33f94cd24ba9846730d9ff7c36cb
record_format	dspace
spelling	oai:doaj.org-article:96ba33f94cd24ba9846730d9ff7c36cb2021-12-02T02:11:04ZSmoking results in accumulation of ectopic fat in the liver1178-7007https://doaj.org/article/96ba33f94cd24ba9846730d9ff7c36cb2019-07-01T00:00:00Zhttps://www.dovepress.com/smoking-results-in-accumulation-of-ectopic-fat-in-the-liver-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ayako Kato,1 Yuanying Li,1 Atsuhiko Ota,1 Hisao Naito,1 Hiroya Yamada,2 Takashi Nihashi,3 Yo Hotta,4 Chifa Chiang,5 Yoshihisa Hirakawa,5 Atsuko Aoyama,5,6 Koji Tamakoshi,7 Hiroshi Yatsuya1,51Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 3Department of Radiology, Komaki City Hospital, Komaki, Aichi, Japan; 4Toyoda Gosei Co., Ltd, Medical and Hygiene Designing Department, Inazawa, Aichi, Japan; 5Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 6Nagoya University of Arts and Sciences, Nissin, Aichi, Japan; 7Department of Nursing, Nagoya University School of Health Sciences, Nagoya, Aichi, JapanObjective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin.Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance.Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074).Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.Keywords: intrahepatic fat, cigarette smoking, adiponectin, triglycerides, cross-sectional study  Kato ALi YOta ANaito HYamada HNihashi THotta YChiang CHirakawa YAoyama ATamakoshi KYatsuya HDove Medical Pressarticleintrahepatic fatcigarette smokingadiponectintriglyceridescross-sectional study.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1075-1080 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	intrahepatic fat cigarette smoking adiponectin triglycerides cross-sectional study. Specialties of internal medicine RC581-951
spellingShingle	intrahepatic fat cigarette smoking adiponectin triglycerides cross-sectional study. Specialties of internal medicine RC581-951 Kato A Li Y Ota A Naito H Yamada H Nihashi T Hotta Y Chiang C Hirakawa Y Aoyama A Tamakoshi K Yatsuya H Smoking results in accumulation of ectopic fat in the liver
description	Ayako Kato,1 Yuanying Li,1 Atsuhiko Ota,1 Hisao Naito,1 Hiroya Yamada,2 Takashi Nihashi,3 Yo Hotta,4 Chifa Chiang,5 Yoshihisa Hirakawa,5 Atsuko Aoyama,5,6 Koji Tamakoshi,7 Hiroshi Yatsuya1,51Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 3Department of Radiology, Komaki City Hospital, Komaki, Aichi, Japan; 4Toyoda Gosei Co., Ltd, Medical and Hygiene Designing Department, Inazawa, Aichi, Japan; 5Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; 6Nagoya University of Arts and Sciences, Nissin, Aichi, Japan; 7Department of Nursing, Nagoya University School of Health Sciences, Nagoya, Aichi, JapanObjective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin.Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance.Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074).Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.Keywords: intrahepatic fat, cigarette smoking, adiponectin, triglycerides, cross-sectional study
format	article
author	Kato A Li Y Ota A Naito H Yamada H Nihashi T Hotta Y Chiang C Hirakawa Y Aoyama A Tamakoshi K Yatsuya H
author_facet	Kato A Li Y Ota A Naito H Yamada H Nihashi T Hotta Y Chiang C Hirakawa Y Aoyama A Tamakoshi K Yatsuya H
author_sort	Kato A
title	Smoking results in accumulation of ectopic fat in the liver
title_short	Smoking results in accumulation of ectopic fat in the liver
title_full	Smoking results in accumulation of ectopic fat in the liver
title_fullStr	Smoking results in accumulation of ectopic fat in the liver
title_full_unstemmed	Smoking results in accumulation of ectopic fat in the liver
title_sort	smoking results in accumulation of ectopic fat in the liver
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/96ba33f94cd24ba9846730d9ff7c36cb
work_keys_str_mv	AT katoa smokingresultsinaccumulationofectopicfatintheliver AT liy smokingresultsinaccumulationofectopicfatintheliver AT otaa smokingresultsinaccumulationofectopicfatintheliver AT naitoh smokingresultsinaccumulationofectopicfatintheliver AT yamadah smokingresultsinaccumulationofectopicfatintheliver AT nihashit smokingresultsinaccumulationofectopicfatintheliver AT hottay smokingresultsinaccumulationofectopicfatintheliver AT chiangc smokingresultsinaccumulationofectopicfatintheliver AT hirakaway smokingresultsinaccumulationofectopicfatintheliver AT aoyamaa smokingresultsinaccumulationofectopicfatintheliver AT tamakoshik smokingresultsinaccumulationofectopicfatintheliver AT yatsuyah smokingresultsinaccumulationofectopicfatintheliver
_version_	1718402662649561088

Smoking results in accumulation of ectopic fat in the liver

Ejemplares similares