Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin, muscles, bones, and viscera to detect touch and temperature as well as to mediate proprioception and many types of interoception. In addition, the somatosensory system conveys the clinically relevant noxious...

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Autores principales:	Minh Q Nguyen, Lars J von Buchholtz, Ashlie N Reker, Nicholas JP Ryba, Steve Davidson
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	somatosensation dorsal root ganglia transcriptomics pain itch Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/96ba54cd83344ce59dc3bf13a754b148
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spelling	oai:doaj.org-article:96ba54cd83344ce59dc3bf13a754b1482021-11-26T13:22:21ZSingle-nucleus transcriptomic analysis of human dorsal root ganglion neurons10.7554/eLife.717522050-084Xe71752https://doaj.org/article/96ba54cd83344ce59dc3bf13a754b1482021-11-01T00:00:00Zhttps://elifesciences.org/articles/71752https://doaj.org/toc/2050-084XSomatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin, muscles, bones, and viscera to detect touch and temperature as well as to mediate proprioception and many types of interoception. In addition, the somatosensory system conveys the clinically relevant noxious sensations of pain and itch. Here, we used single nuclear transcriptomics to characterize transcriptomic classes of human DRG neurons that detect these diverse types of stimuli. Notably, multiple types of human DRG neurons have transcriptomic features that resemble their mouse counterparts although expression of genes considered important for sensory function often differed between species. More unexpectedly, we identified several transcriptomic classes with no clear equivalent in the other species. This dataset should serve as a valuable resource for the community, for example as means of focusing translational efforts on molecules with conserved expression across species.Minh Q NguyenLars J von BuchholtzAshlie N RekerNicholas JP RybaSteve DavidsoneLife Sciences Publications Ltdarticlesomatosensationdorsal root gangliatranscriptomicspainitchMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	somatosensation dorsal root ganglia transcriptomics pain itch Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	somatosensation dorsal root ganglia transcriptomics pain itch Medicine R Science Q Biology (General) QH301-705.5 Minh Q Nguyen Lars J von Buchholtz Ashlie N Reker Nicholas JP Ryba Steve Davidson Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
description	Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin, muscles, bones, and viscera to detect touch and temperature as well as to mediate proprioception and many types of interoception. In addition, the somatosensory system conveys the clinically relevant noxious sensations of pain and itch. Here, we used single nuclear transcriptomics to characterize transcriptomic classes of human DRG neurons that detect these diverse types of stimuli. Notably, multiple types of human DRG neurons have transcriptomic features that resemble their mouse counterparts although expression of genes considered important for sensory function often differed between species. More unexpectedly, we identified several transcriptomic classes with no clear equivalent in the other species. This dataset should serve as a valuable resource for the community, for example as means of focusing translational efforts on molecules with conserved expression across species.
format	article
author	Minh Q Nguyen Lars J von Buchholtz Ashlie N Reker Nicholas JP Ryba Steve Davidson
author_facet	Minh Q Nguyen Lars J von Buchholtz Ashlie N Reker Nicholas JP Ryba Steve Davidson
author_sort	Minh Q Nguyen
title	Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
title_short	Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
title_full	Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
title_fullStr	Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
title_full_unstemmed	Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
title_sort	single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/96ba54cd83344ce59dc3bf13a754b148
work_keys_str_mv	AT minhqnguyen singlenucleustranscriptomicanalysisofhumandorsalrootganglionneurons AT larsjvonbuchholtz singlenucleustranscriptomicanalysisofhumandorsalrootganglionneurons AT ashlienreker singlenucleustranscriptomicanalysisofhumandorsalrootganglionneurons AT nicholasjpryba singlenucleustranscriptomicanalysisofhumandorsalrootganglionneurons AT stevedavidson singlenucleustranscriptomicanalysisofhumandorsalrootganglionneurons
_version_	1718409306207944704

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

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