The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

GalNAc transferases’ (GalNAc-Ts) catalytic domains are connected to a lectin domain through a flexible linker. Here the authors present a structural analysis of GalNAc-T4 that implicates the linker region as modulator of the orientations of the lectin domain, which in turn imparts substrate specific...

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Autores principales: Matilde de las Rivas, Erandi Lira-Navarrete, Earnest James Paul Daniel, Ismael Compañón, Helena Coelho, Ana Diniz, Jesús Jiménez-Barbero, Jesús M. Peregrina, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Gonzalo Jiménez-Osés, Thomas A. Gerken, Ramon Hurtado-Guerrero
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/96c013e274ef4775a780ce73240387ed
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spelling oai:doaj.org-article:96c013e274ef4775a780ce73240387ed2021-12-02T14:41:19ZThe interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences10.1038/s41467-017-02006-02041-1723https://doaj.org/article/96c013e274ef4775a780ce73240387ed2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02006-0https://doaj.org/toc/2041-1723GalNAc transferases’ (GalNAc-Ts) catalytic domains are connected to a lectin domain through a flexible linker. Here the authors present a structural analysis of GalNAc-T4 that implicates the linker region as modulator of the orientations of the lectin domain, which in turn imparts substrate specificity.Matilde de las RivasErandi Lira-NavarreteEarnest James Paul DanielIsmael CompañónHelena CoelhoAna DinizJesús Jiménez-BarberoJesús M. PeregrinaHenrik ClausenFrancisco CorzanaFilipa MarceloGonzalo Jiménez-OsésThomas A. GerkenRamon Hurtado-GuerreroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matilde de las Rivas
Erandi Lira-Navarrete
Earnest James Paul Daniel
Ismael Compañón
Helena Coelho
Ana Diniz
Jesús Jiménez-Barbero
Jesús M. Peregrina
Henrik Clausen
Francisco Corzana
Filipa Marcelo
Gonzalo Jiménez-Osés
Thomas A. Gerken
Ramon Hurtado-Guerrero
The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
description GalNAc transferases’ (GalNAc-Ts) catalytic domains are connected to a lectin domain through a flexible linker. Here the authors present a structural analysis of GalNAc-T4 that implicates the linker region as modulator of the orientations of the lectin domain, which in turn imparts substrate specificity.
format article
author Matilde de las Rivas
Erandi Lira-Navarrete
Earnest James Paul Daniel
Ismael Compañón
Helena Coelho
Ana Diniz
Jesús Jiménez-Barbero
Jesús M. Peregrina
Henrik Clausen
Francisco Corzana
Filipa Marcelo
Gonzalo Jiménez-Osés
Thomas A. Gerken
Ramon Hurtado-Guerrero
author_facet Matilde de las Rivas
Erandi Lira-Navarrete
Earnest James Paul Daniel
Ismael Compañón
Helena Coelho
Ana Diniz
Jesús Jiménez-Barbero
Jesús M. Peregrina
Henrik Clausen
Francisco Corzana
Filipa Marcelo
Gonzalo Jiménez-Osés
Thomas A. Gerken
Ramon Hurtado-Guerrero
author_sort Matilde de las Rivas
title The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
title_short The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
title_full The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
title_fullStr The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
title_full_unstemmed The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences
title_sort interdomain flexible linker of the polypeptide galnac transferases dictates their long-range glycosylation preferences
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/96c013e274ef4775a780ce73240387ed
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