Chapter 15: disease gene prioritization.

Disease-causing aberrations in the normal function of a gene define that gene as a disease gene. Proving a causal link between a gene and a disease experimentally is expensive and time-consuming. Comprehensive prioritization of candidate genes prior to experimental testing drastically reduces the as...

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Autor principal:	Yana Bromberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/96c3201af4fe4d26a8d4aeeed96cc102
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spelling	oai:doaj.org-article:96c3201af4fe4d26a8d4aeeed96cc1022021-11-18T05:52:12ZChapter 15: disease gene prioritization.1553-734X1553-735810.1371/journal.pcbi.1002902https://doaj.org/article/96c3201af4fe4d26a8d4aeeed96cc1022013-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23633938/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Disease-causing aberrations in the normal function of a gene define that gene as a disease gene. Proving a causal link between a gene and a disease experimentally is expensive and time-consuming. Comprehensive prioritization of candidate genes prior to experimental testing drastically reduces the associated costs. Computational gene prioritization is based on various pieces of correlative evidence that associate each gene with the given disease and suggest possible causal links. A fair amount of this evidence comes from high-throughput experimentation. Thus, well-developed methods are necessary to reliably deal with the quantity of information at hand. Existing gene prioritization techniques already significantly improve the outcomes of targeted experimental studies. Faster and more reliable techniques that account for novel data types are necessary for the development of new diagnostics, treatments, and cure for many diseases.Yana BrombergPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 4, p e1002902 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yana Bromberg Chapter 15: disease gene prioritization.
description	Disease-causing aberrations in the normal function of a gene define that gene as a disease gene. Proving a causal link between a gene and a disease experimentally is expensive and time-consuming. Comprehensive prioritization of candidate genes prior to experimental testing drastically reduces the associated costs. Computational gene prioritization is based on various pieces of correlative evidence that associate each gene with the given disease and suggest possible causal links. A fair amount of this evidence comes from high-throughput experimentation. Thus, well-developed methods are necessary to reliably deal with the quantity of information at hand. Existing gene prioritization techniques already significantly improve the outcomes of targeted experimental studies. Faster and more reliable techniques that account for novel data types are necessary for the development of new diagnostics, treatments, and cure for many diseases.
format	article
author	Yana Bromberg
author_facet	Yana Bromberg
author_sort	Yana Bromberg
title	Chapter 15: disease gene prioritization.
title_short	Chapter 15: disease gene prioritization.
title_full	Chapter 15: disease gene prioritization.
title_fullStr	Chapter 15: disease gene prioritization.
title_full_unstemmed	Chapter 15: disease gene prioritization.
title_sort	chapter 15: disease gene prioritization.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/96c3201af4fe4d26a8d4aeeed96cc102
work_keys_str_mv	AT yanabromberg chapter15diseasegeneprioritization
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Chapter 15: disease gene prioritization.

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