Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

Hsp70s are highly conserved molecular chaperones that play multiple essential roles in maintaining cellular protein homeostasis. Here, the authors provide structural evidence for active substrate release by Hsp70s upon ATP binding and provide insight into the molecular mechanism of ATP-driven Hsp70...

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Autores principales: Jiao Yang, Yinong Zong, Jiayue Su, Hongtao Li, Huanyu Zhu, Linda Columbus, Lei Zhou, Qinglian Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/96c59e172310474e9274be9a59826a04
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