Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis

ABSTRACT Aspergillus fumigatus, an opportunistic fungal pathogen, spreads in the environment by releasing numerous conidia that are capable of reaching the small alveolar airways of mammalian hosts. In otherwise healthy individuals, macrophages are responsible for rapidly phagocytosing and eliminati...

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Autores principales: Daniel Schlam, Johnathan Canton, Marvin Carreño, Hannah Kopinski, Spencer A. Freeman, Sergio Grinstein, Gregory D. Fairn
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
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Acceso en línea:https://doaj.org/article/96c75fd9f25e4a2d90950ddcc356f465
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