Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis

Abstract In-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volu...

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Autores principales:	Melanie Haidegger, Markus Kneihsl, Kurt Niederkorn, Hannes Deutschmann, Harald Mangge, Christian Vetta, Michael Augustin, Gerit Wünsch, Simon Fandler-Höfler, Susanna Horner, Christian Enzinger, Thomas Gattringer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96c7f491c19841828958689edfffea87
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spelling	oai:doaj.org-article:96c7f491c19841828958689edfffea872021-12-02T18:49:30ZBlood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis10.1038/s41598-021-95135-y2045-2322https://doaj.org/article/96c7f491c19841828958689edfffea872021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95135-yhttps://doaj.org/toc/2045-2322Abstract In-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been associated with progressive atherosclerosis. We investigated the role of CRP, NLR, PLR and MPV on the development of intracranial ISR and recurrent stroke risk. We retrospectively included all patients who had undergone stenting of symptomatic ICAS at our university hospital between 2005 and 2016. ISR (≥ 50% stenosis) was diagnosed by regular Duplex sonography follow-up studies and confirmed by digital subtraction angiography or computed tomography angiography (mean follow-up duration: 5 years). Laboratory parameters were documented before stenting, at the time of restenosis and at last clinical follow-up. Of 115 patients (mean age: 73 ± 13 years; female: 34%), 38 (33%) developed ISR. The assessed laboratory parameters did not differ between patients with ISR and those without (p > 0.1). While ISR was associated with the occurrence of recurrent ischemic stroke (p = 0.003), CRP, NLR, PLR and MPV were not predictive of such events (p > 0.1). Investigated blood biomarkers of progressive atherosclerosis were not predictive for the occurrence of ISR or recurrent ischemic stroke after ICAS stenting during a 5-year follow-up.Melanie HaideggerMarkus KneihslKurt NiederkornHannes DeutschmannHarald ManggeChristian VettaMichael AugustinGerit WünschSimon Fandler-HöflerSusanna HornerChristian EnzingerThomas GattringerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Melanie Haidegger Markus Kneihsl Kurt Niederkorn Hannes Deutschmann Harald Mangge Christian Vetta Michael Augustin Gerit Wünsch Simon Fandler-Höfler Susanna Horner Christian Enzinger Thomas Gattringer Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
description	Abstract In-stent restenosis (ISR) represents a major complication after stenting of intracranial artery stenosis (ICAS). Biomarkers derived from routine blood sampling including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) have been associated with progressive atherosclerosis. We investigated the role of CRP, NLR, PLR and MPV on the development of intracranial ISR and recurrent stroke risk. We retrospectively included all patients who had undergone stenting of symptomatic ICAS at our university hospital between 2005 and 2016. ISR (≥ 50% stenosis) was diagnosed by regular Duplex sonography follow-up studies and confirmed by digital subtraction angiography or computed tomography angiography (mean follow-up duration: 5 years). Laboratory parameters were documented before stenting, at the time of restenosis and at last clinical follow-up. Of 115 patients (mean age: 73 ± 13 years; female: 34%), 38 (33%) developed ISR. The assessed laboratory parameters did not differ between patients with ISR and those without (p > 0.1). While ISR was associated with the occurrence of recurrent ischemic stroke (p = 0.003), CRP, NLR, PLR and MPV were not predictive of such events (p > 0.1). Investigated blood biomarkers of progressive atherosclerosis were not predictive for the occurrence of ISR or recurrent ischemic stroke after ICAS stenting during a 5-year follow-up.
format	article
author	Melanie Haidegger Markus Kneihsl Kurt Niederkorn Hannes Deutschmann Harald Mangge Christian Vetta Michael Augustin Gerit Wünsch Simon Fandler-Höfler Susanna Horner Christian Enzinger Thomas Gattringer
author_facet	Melanie Haidegger Markus Kneihsl Kurt Niederkorn Hannes Deutschmann Harald Mangge Christian Vetta Michael Augustin Gerit Wünsch Simon Fandler-Höfler Susanna Horner Christian Enzinger Thomas Gattringer
author_sort	Melanie Haidegger
title	Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
title_short	Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
title_full	Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
title_fullStr	Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
title_full_unstemmed	Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
title_sort	blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96c7f491c19841828958689edfffea87
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Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis

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