Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop

Abstract The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of br...

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Autores principales:	Morgan V. Fedorchak, Ian P. Conner, Joel S. Schuman, Anthony Cugini, Steven R. Little
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96ca231233a64b9c872534f82defeb1b
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spelling	oai:doaj.org-article:96ca231233a64b9c872534f82defeb1b2021-12-02T16:06:13ZLong Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop10.1038/s41598-017-09379-82045-2322https://doaj.org/article/96ca231233a64b9c872534f82defeb1b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09379-8https://doaj.org/toc/2045-2322Abstract The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of brimonidine from the GMS drops and gel properties were quantified. A single brimonidine-loaded GMS drop was administered to 5 normotensive rabbits and intraocular pressure (IOP) was monitored for 28 days. Here we report that IOP reduction in rabbits receiving a single brimonidine GMS drop was comparable to that of rabbits receiving twice daily, standard brimonidine drops. GMS drops were retained in the inferior fornix in all animals for the length of the study. Our results suggest in vivo efficacy over 28 days from a single GMS drop and a potential decrease in systemic absorption, based on a lack of substantial IOP effects on the fellow untreated eye, compared to brimonidine twice-daily eye drops. To our knowledge, this represents the first long-term, drug-releasing depot that can be administered as a traditional eye drop.Morgan V. FedorchakIan P. ConnerJoel S. SchumanAnthony CuginiSteven R. LittleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Morgan V. Fedorchak Ian P. Conner Joel S. Schuman Anthony Cugini Steven R. Little Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
description	Abstract The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of brimonidine from the GMS drops and gel properties were quantified. A single brimonidine-loaded GMS drop was administered to 5 normotensive rabbits and intraocular pressure (IOP) was monitored for 28 days. Here we report that IOP reduction in rabbits receiving a single brimonidine GMS drop was comparable to that of rabbits receiving twice daily, standard brimonidine drops. GMS drops were retained in the inferior fornix in all animals for the length of the study. Our results suggest in vivo efficacy over 28 days from a single GMS drop and a potential decrease in systemic absorption, based on a lack of substantial IOP effects on the fellow untreated eye, compared to brimonidine twice-daily eye drops. To our knowledge, this represents the first long-term, drug-releasing depot that can be administered as a traditional eye drop.
format	article
author	Morgan V. Fedorchak Ian P. Conner Joel S. Schuman Anthony Cugini Steven R. Little
author_facet	Morgan V. Fedorchak Ian P. Conner Joel S. Schuman Anthony Cugini Steven R. Little
author_sort	Morgan V. Fedorchak
title	Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
title_short	Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
title_full	Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
title_fullStr	Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
title_full_unstemmed	Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop
title_sort	long term glaucoma drug delivery using a topically retained gel/microsphere eye drop
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/96ca231233a64b9c872534f82defeb1b
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Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop

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