Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice

Abstract The tuberous sclerosis complex 1/2 (TSC1/2) is an endogenous regulator of the mechanistic target of rapamycin (mTOR). While mTOR has been shown to play an important role in health and aging, the role of TSC1/2 in aging has not been fully investigated. In the current study, a constitutive TS...

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Autores principales: Hong-Mei Zhang, Vivian Diaz, Michael E. Walsh, Yiqiang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/96ca9655468d43eba1428c6922390f67
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