Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct int...

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Autores principales: Mi-Sun Kang, Eunjin Ryu, Seung-Won Lee, Jieun Park, Na Young Ha, Jae Sun Ra, Yeong Jae Kim, Jinwoo Kim, Mohamed Abdel-Rahman, Su Hyung Park, Kyoo-young Lee, Hajin Kim, Sukhyun Kang, Kyungjae Myung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/96cbddeb94864108881d91854ff5ff84
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Sumario:Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.

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