Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes

Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct int...

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Autores principales: Mi-Sun Kang, Eunjin Ryu, Seung-Won Lee, Jieun Park, Na Young Ha, Jae Sun Ra, Yeong Jae Kim, Jinwoo Kim, Mohamed Abdel-Rahman, Su Hyung Park, Kyoo-young Lee, Hajin Kim, Sukhyun Kang, Kyungjae Myung
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/96cbddeb94864108881d91854ff5ff84
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spelling oai:doaj.org-article:96cbddeb94864108881d91854ff5ff842021-12-02T17:02:03ZRegulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes10.1038/s41467-019-10376-w2041-1723https://doaj.org/article/96cbddeb94864108881d91854ff5ff842019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10376-whttps://doaj.org/toc/2041-1723Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.Mi-Sun KangEunjin RyuSeung-Won LeeJieun ParkNa Young HaJae Sun RaYeong Jae KimJinwoo KimMohamed Abdel-RahmanSu Hyung ParkKyoo-young LeeHajin KimSukhyun KangKyungjae MyungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mi-Sun Kang
Eunjin Ryu
Seung-Won Lee
Jieun Park
Na Young Ha
Jae Sun Ra
Yeong Jae Kim
Jinwoo Kim
Mohamed Abdel-Rahman
Su Hyung Park
Kyoo-young Lee
Hajin Kim
Sukhyun Kang
Kyungjae Myung
Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
description Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.
format article
author Mi-Sun Kang
Eunjin Ryu
Seung-Won Lee
Jieun Park
Na Young Ha
Jae Sun Ra
Yeong Jae Kim
Jinwoo Kim
Mohamed Abdel-Rahman
Su Hyung Park
Kyoo-young Lee
Hajin Kim
Sukhyun Kang
Kyungjae Myung
author_facet Mi-Sun Kang
Eunjin Ryu
Seung-Won Lee
Jieun Park
Na Young Ha
Jae Sun Ra
Yeong Jae Kim
Jinwoo Kim
Mohamed Abdel-Rahman
Su Hyung Park
Kyoo-young Lee
Hajin Kim
Sukhyun Kang
Kyungjae Myung
author_sort Mi-Sun Kang
title Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
title_short Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
title_full Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
title_fullStr Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
title_full_unstemmed Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
title_sort regulation of pcna cycling on replicating dna by rfc and rfc-like complexes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/96cbddeb94864108881d91854ff5ff84
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