Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes chemoresistance in preclinical cancer models.

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Autores principales:	Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
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spelling	oai:doaj.org-article:96cc5e262fc1481b86eceff834f1a9ce2021-12-02T15:54:54ZMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance10.1038/s41467-021-23071-62041-1723https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23071-6https://doaj.org/toc/2041-1723Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes chemoresistance in preclinical cancer models.Emily L. GiddingsDevin P. ChampagneMeng-Han WuJoshua M. LaffinTina M. ThorntonFelipe Valenca-PereiraRachel Culp-HillKaren A. FortnerNatalia RomeroJames EastPhoebe CaoHugo Arias-PulidoKaratatiwant S. SidhuBrian SilverstrimYoonseok KamShana KelleyMark PereiraSusan E. BatesJanice Y. BunnSteven N. FieringDwight E. MatthewsRobert W. RobeyDomink StichAngelo D’AlessandroMercedes RinconNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily L. Giddings Devin P. Champagne Meng-Han Wu Joshua M. Laffin Tina M. Thornton Felipe Valenca-Pereira Rachel Culp-Hill Karen A. Fortner Natalia Romero James East Phoebe Cao Hugo Arias-Pulido Karatatiwant S. Sidhu Brian Silverstrim Yoonseok Kam Shana Kelley Mark Pereira Susan E. Bates Janice Y. Bunn Steven N. Fiering Dwight E. Matthews Robert W. Robey Domink Stich Angelo D’Alessandro Mercedes Rincon Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
description	Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes chemoresistance in preclinical cancer models.
format	article
author	Emily L. Giddings Devin P. Champagne Meng-Han Wu Joshua M. Laffin Tina M. Thornton Felipe Valenca-Pereira Rachel Culp-Hill Karen A. Fortner Natalia Romero James East Phoebe Cao Hugo Arias-Pulido Karatatiwant S. Sidhu Brian Silverstrim Yoonseok Kam Shana Kelley Mark Pereira Susan E. Bates Janice Y. Bunn Steven N. Fiering Dwight E. Matthews Robert W. Robey Domink Stich Angelo D’Alessandro Mercedes Rincon
author_facet	Emily L. Giddings Devin P. Champagne Meng-Han Wu Joshua M. Laffin Tina M. Thornton Felipe Valenca-Pereira Rachel Culp-Hill Karen A. Fortner Natalia Romero James East Phoebe Cao Hugo Arias-Pulido Karatatiwant S. Sidhu Brian Silverstrim Yoonseok Kam Shana Kelley Mark Pereira Susan E. Bates Janice Y. Bunn Steven N. Fiering Dwight E. Matthews Robert W. Robey Domink Stich Angelo D’Alessandro Mercedes Rincon
author_sort	Emily L. Giddings
title	Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
title_short	Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
title_full	Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
title_fullStr	Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
title_full_unstemmed	Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
title_sort	mitochondrial atp fuels abc transporter-mediated drug efflux in cancer chemoresistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
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Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

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