Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes chemoresistance in preclinical cancer models.
Enregistré dans:
Auteurs principaux: | Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
ABC del duelo /
par: Yávar, Gonzalo
Publié: (2017) -
ABC : el pensamiento político de la Democracia Cristiana /
Publié: (1994) -
ABC : el pensamiento político de la Democracia Cristiana /
Publié: (2002) -
Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
par: Sajad Dar, et autres
Publié: (2017) -
Mediation Protocol of the ABC Conference
Publié: (2017)