Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have b...

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Autores principales:	Carli L. Poisson, Liv Engel, Benjamin T. Saunders
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dopamine striatum addiction substance use disorder animal model nigrostriatal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/96cec8e6d48240f3b47c22c912611c4f
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spelling	oai:doaj.org-article:96cec8e6d48240f3b47c22c912611c4f2021-11-09T16:46:50ZDopamine Circuit Mechanisms of Addiction-Like Behaviors1662-511010.3389/fncir.2021.752420https://doaj.org/article/96cec8e6d48240f3b47c22c912611c4f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncir.2021.752420/fullhttps://doaj.org/toc/1662-5110Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have been made to model features of these criteria in non-human animal research subjects, for insight into the underlying neurobiological mechanisms. Here we review evidence from rodent models of SUD-inspired criteria, focusing on the role of the striatal dopamine system. We identify distinct mesostriatal and nigrostriatal dopamine circuit functions in behavioral outcomes that are relevant to addictions and SUDs. This work suggests that striatal dopamine is essential for not only positive symptom features of SUDs, such as elevated intake and craving, but also for impairments in decision making that underlie compulsive behavior, reduced sociality, and risk taking. Understanding the functional heterogeneity of the dopamine system and related networks can offer insight into this complex symptomatology and may lead to more targeted treatments.Carli L. PoissonCarli L. PoissonCarli L. PoissonLiv EngelLiv EngelBenjamin T. SaundersBenjamin T. SaundersBenjamin T. SaundersFrontiers Media S.A.articledopaminestriatumaddictionsubstance use disorderanimal modelnigrostriatalNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neural Circuits, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dopamine striatum addiction substance use disorder animal model nigrostriatal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	dopamine striatum addiction substance use disorder animal model nigrostriatal Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Carli L. Poisson Carli L. Poisson Carli L. Poisson Liv Engel Liv Engel Benjamin T. Saunders Benjamin T. Saunders Benjamin T. Saunders Dopamine Circuit Mechanisms of Addiction-Like Behaviors
description	Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have been made to model features of these criteria in non-human animal research subjects, for insight into the underlying neurobiological mechanisms. Here we review evidence from rodent models of SUD-inspired criteria, focusing on the role of the striatal dopamine system. We identify distinct mesostriatal and nigrostriatal dopamine circuit functions in behavioral outcomes that are relevant to addictions and SUDs. This work suggests that striatal dopamine is essential for not only positive symptom features of SUDs, such as elevated intake and craving, but also for impairments in decision making that underlie compulsive behavior, reduced sociality, and risk taking. Understanding the functional heterogeneity of the dopamine system and related networks can offer insight into this complex symptomatology and may lead to more targeted treatments.
format	article
author	Carli L. Poisson Carli L. Poisson Carli L. Poisson Liv Engel Liv Engel Benjamin T. Saunders Benjamin T. Saunders Benjamin T. Saunders
author_facet	Carli L. Poisson Carli L. Poisson Carli L. Poisson Liv Engel Liv Engel Benjamin T. Saunders Benjamin T. Saunders Benjamin T. Saunders
author_sort	Carli L. Poisson
title	Dopamine Circuit Mechanisms of Addiction-Like Behaviors
title_short	Dopamine Circuit Mechanisms of Addiction-Like Behaviors
title_full	Dopamine Circuit Mechanisms of Addiction-Like Behaviors
title_fullStr	Dopamine Circuit Mechanisms of Addiction-Like Behaviors
title_full_unstemmed	Dopamine Circuit Mechanisms of Addiction-Like Behaviors
title_sort	dopamine circuit mechanisms of addiction-like behaviors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/96cec8e6d48240f3b47c22c912611c4f
work_keys_str_mv	AT carlilpoisson dopaminecircuitmechanismsofaddictionlikebehaviors AT carlilpoisson dopaminecircuitmechanismsofaddictionlikebehaviors AT carlilpoisson dopaminecircuitmechanismsofaddictionlikebehaviors AT livengel dopaminecircuitmechanismsofaddictionlikebehaviors AT livengel dopaminecircuitmechanismsofaddictionlikebehaviors AT benjamintsaunders dopaminecircuitmechanismsofaddictionlikebehaviors AT benjamintsaunders dopaminecircuitmechanismsofaddictionlikebehaviors AT benjamintsaunders dopaminecircuitmechanismsofaddictionlikebehaviors
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Dopamine Circuit Mechanisms of Addiction-Like Behaviors

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