Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.

<h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to su...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jian Wang, Jiqing Zhao, Mengjing Shi, Yu Ding, Huiqin Sun, Fahuan Yuan, Zhongmin Zou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96cf0e82264e4b4aa2207934c54dff5a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96cf0e82264e4b4aa2207934c54dff5a
record_format	dspace
spelling	oai:doaj.org-article:96cf0e82264e4b4aa2207934c54dff5a2021-11-18T08:31:44ZElevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0089223https://doaj.org/article/96cf0e82264e4b4aa2207934c54dff5a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586608/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.<h4>Methodology/principal findings</h4>The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).<h4>Conclusions/significance</h4>This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.Jian WangJiqing ZhaoMengjing ShiYu DingHuiqin SunFahuan YuanZhongmin ZouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89223 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
description	<h4>Background</h4>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.<h4>Methodology/principal findings</h4>The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).<h4>Conclusions/significance</h4>This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.
format	article
author	Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou
author_facet	Jian Wang Jiqing Zhao Mengjing Shi Yu Ding Huiqin Sun Fahuan Yuan Zhongmin Zou
author_sort	Jian Wang
title	Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
title_short	Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
title_full	Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
title_fullStr	Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
title_full_unstemmed	Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
title_sort	elevated expression of mir-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/96cf0e82264e4b4aa2207934c54dff5a
work_keys_str_mv	AT jianwang elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT jiqingzhao elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT mengjingshi elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT yuding elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT huiqinsun elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT fahuanyuan elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis AT zhongminzou elevatedexpressionofmir210predictspoorsurvivalofcancerpatientsasystematicreviewandmetaanalysis
_version_	1718421697862828032

Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.

Ejemplares similares