Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration

Abstract This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intr...

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Autores principales:	Nobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Yuji Yamamoto, Kengo Yoshii, Koji Kitazawa, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, Junji Hamuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
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spelling	oai:doaj.org-article:96cf22a30aaf4687a79a10be48d9748d2021-12-02T15:07:47ZDistinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration10.1038/s41598-018-28484-w2045-2322https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28484-whttps://doaj.org/toc/2045-2322Abstract This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p = 0.03) but was almost identical to that in the control group (p = 0.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r = 0.78, p < 0.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r = 0.68, p = 0.002) and IL-8 and MCP-1 (r = 0.68, p = 0.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p = 0.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.Nobuhiro TeraoHideki KoizumiKentaro KojimaTetsuya YamagishiYuji YamamotoKengo YoshiiKoji KitazawaAsako HiragaMunetoyo TodaShigeru KinoshitaChie SotozonoJunji HamuroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nobuhiro Terao Hideki Koizumi Kentaro Kojima Tetsuya Yamagishi Yuji Yamamoto Kengo Yoshii Koji Kitazawa Asako Hiraga Munetoyo Toda Shigeru Kinoshita Chie Sotozono Junji Hamuro Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
description	Abstract This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p = 0.03) but was almost identical to that in the control group (p = 0.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r = 0.78, p < 0.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r = 0.68, p = 0.002) and IL-8 and MCP-1 (r = 0.68, p = 0.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p = 0.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.
format	article
author	Nobuhiro Terao Hideki Koizumi Kentaro Kojima Tetsuya Yamagishi Yuji Yamamoto Kengo Yoshii Koji Kitazawa Asako Hiraga Munetoyo Toda Shigeru Kinoshita Chie Sotozono Junji Hamuro
author_facet	Nobuhiro Terao Hideki Koizumi Kentaro Kojima Tetsuya Yamagishi Yuji Yamamoto Kengo Yoshii Koji Kitazawa Asako Hiraga Munetoyo Toda Shigeru Kinoshita Chie Sotozono Junji Hamuro
author_sort	Nobuhiro Terao
title	Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
title_short	Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
title_full	Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
title_fullStr	Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
title_full_unstemmed	Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration
title_sort	distinct aqueous humour cytokine profiles of patients with pachychoroid neovasculopathy and neovascular age-related macular degeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/96cf22a30aaf4687a79a10be48d9748d
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Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration

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