Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells

Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells

Abstract Background Self-emulsifying drug delivery systems (SEDDSs) have attracted attention because of their effects on solubility and bioavailability of lipophilic compounds. Herein, a SEDDS loaded with lycopene purified from red guava (nanoLPG) was produced. The nanoemulsion was characterized usi...

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Main Authors: Andreanne G. Vasconcelos, Ana Luisa A. N. Barros, Wanessa F. Cabral, Daniel C. Moreira, Ingrid Gracielle M. da Silva, Amandda É. Silva-Carvalho, Miguel P. de Almeida, Lucas F. F. Albuquerque, Raimunda C. dos Santos, Ana Karolinne S. Brito, Felipe Saldanha-Araújo, Daniel D. R. Arcanjo, Maria do Carmo C. Martins, Tatiana K. dos S. Borges, Sônia N. Báo, Alexandra Plácido, Peter Eaton, Selma A. S. Kuckelhaus, José Roberto S. A. Leite
Format: article
Language:EN
Published: BMC 2021
Subjects:
Nanomedicine
Self-emulsifying
Guava fruit
Carotenoids
Antitumoral
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/96d0dd8b92374717be7fb9fc33612257
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https://doaj.org/article/96d0dd8b92374717be7fb9fc33612257

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