Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling

Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inf...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Manish Kumar, Aralia Leon Coria, Steve Cornick, Björn Petri, Shyamchand Mayengbam, Humberto B. Jijon, France Moreau, Jane Shearer, Kris Chadee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/96d4615ce4ea4d449b6fdbc7f7f39a95
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:96d4615ce4ea4d449b6fdbc7f7f39a95
record_format dspace
spelling oai:doaj.org-article:96d4615ce4ea4d449b6fdbc7f7f39a952021-12-02T17:32:25ZIncreased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling10.1038/s41467-019-14182-22041-1723https://doaj.org/article/96d4615ce4ea4d449b6fdbc7f7f39a952020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14182-2https://doaj.org/toc/2041-1723Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.Manish KumarAralia Leon CoriaSteve CornickBjörn PetriShyamchand MayengbamHumberto B. JijonFrance MoreauJane ShearerKris ChadeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Manish Kumar
Aralia Leon Coria
Steve Cornick
Björn Petri
Shyamchand Mayengbam
Humberto B. Jijon
France Moreau
Jane Shearer
Kris Chadee
Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
description Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.
format article
author Manish Kumar
Aralia Leon Coria
Steve Cornick
Björn Petri
Shyamchand Mayengbam
Humberto B. Jijon
France Moreau
Jane Shearer
Kris Chadee
author_facet Manish Kumar
Aralia Leon Coria
Steve Cornick
Björn Petri
Shyamchand Mayengbam
Humberto B. Jijon
France Moreau
Jane Shearer
Kris Chadee
author_sort Manish Kumar
title Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_short Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_full Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_fullStr Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_full_unstemmed Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
title_sort increased intestinal permeability exacerbates sepsis through reduced hepatic scd-1 activity and dysregulated iron recycling
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/96d4615ce4ea4d449b6fdbc7f7f39a95
work_keys_str_mv AT manishkumar increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT aralialeoncoria increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT stevecornick increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT bjornpetri increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT shyamchandmayengbam increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT humbertobjijon increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT francemoreau increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT janeshearer increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
AT krischadee increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling
_version_ 1718380321927331840

Ejemplares similares