Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening

Obstructive sleep apnea (OSA) is chronic disorder which is characterized by recurrent pauses of breathing during sleep which leads to hypoxia and its two main pathological sequelae: oxidative stress and chronic inflammation. Both are also associated with cellular senescence. As OSA patients present...

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Autores principales:	Szymon Turkiewicz, Marta Ditmer, Marcin Sochal, Piotr Białasiewicz, Dominik Strzelecki, Agata Gabryelska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	OSA senescence telomere shortening SASP hypoxia inflammation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/96d669c2fe684c0dad823c0fbfb73cd0
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spelling	oai:doaj.org-article:96d669c2fe684c0dad823c0fbfb73cd02021-11-25T17:57:35ZObstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening10.3390/ijms2222125361422-00671661-6596https://doaj.org/article/96d669c2fe684c0dad823c0fbfb73cd02021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12536https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Obstructive sleep apnea (OSA) is chronic disorder which is characterized by recurrent pauses of breathing during sleep which leads to hypoxia and its two main pathological sequelae: oxidative stress and chronic inflammation. Both are also associated with cellular senescence. As OSA patients present with higher prevalence of age-related disorders, such as atrial hypertension or diabetes mellitus type 2, a relationship between OSA and accelerated aging is observable. Furthermore, it has been established that these OSA are associated with telomere shortening. This process in OSA is likely caused by increased oxidative DNA damage due to increased reactive oxygen species levels, DNA repair disruptions, hypoxia, chronic inflammation, and circadian clock disturbances. The aim of the review is to summarize study outcomes on changes in leukocyte telomere length (LTL) in OSA patients and describe possible molecular mechanisms which connect cellular senescence and the pathophysiology of OSA. The majority of OSA patients are characterized by LTL attrition due to oxidative stress, hypoxia and inflammation, which make a kind of positive feedback loop, and circadian clock disturbance.Szymon TurkiewiczMarta DitmerMarcin SochalPiotr BiałasiewiczDominik StrzeleckiAgata GabryelskaMDPI AGarticleOSAsenescencetelomere shorteningSASPhypoxiainflammationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12536, p 12536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	OSA senescence telomere shortening SASP hypoxia inflammation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	OSA senescence telomere shortening SASP hypoxia inflammation Biology (General) QH301-705.5 Chemistry QD1-999 Szymon Turkiewicz Marta Ditmer Marcin Sochal Piotr Białasiewicz Dominik Strzelecki Agata Gabryelska Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
description	Obstructive sleep apnea (OSA) is chronic disorder which is characterized by recurrent pauses of breathing during sleep which leads to hypoxia and its two main pathological sequelae: oxidative stress and chronic inflammation. Both are also associated with cellular senescence. As OSA patients present with higher prevalence of age-related disorders, such as atrial hypertension or diabetes mellitus type 2, a relationship between OSA and accelerated aging is observable. Furthermore, it has been established that these OSA are associated with telomere shortening. This process in OSA is likely caused by increased oxidative DNA damage due to increased reactive oxygen species levels, DNA repair disruptions, hypoxia, chronic inflammation, and circadian clock disturbances. The aim of the review is to summarize study outcomes on changes in leukocyte telomere length (LTL) in OSA patients and describe possible molecular mechanisms which connect cellular senescence and the pathophysiology of OSA. The majority of OSA patients are characterized by LTL attrition due to oxidative stress, hypoxia and inflammation, which make a kind of positive feedback loop, and circadian clock disturbance.
format	article
author	Szymon Turkiewicz Marta Ditmer Marcin Sochal Piotr Białasiewicz Dominik Strzelecki Agata Gabryelska
author_facet	Szymon Turkiewicz Marta Ditmer Marcin Sochal Piotr Białasiewicz Dominik Strzelecki Agata Gabryelska
author_sort	Szymon Turkiewicz
title	Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
title_short	Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
title_full	Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
title_fullStr	Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
title_full_unstemmed	Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening
title_sort	obstructive sleep apnea as an acceleration trigger of cellular senescence processes through telomere shortening
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/96d669c2fe684c0dad823c0fbfb73cd0
work_keys_str_mv	AT szymonturkiewicz obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening AT martaditmer obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening AT marcinsochal obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening AT piotrbiałasiewicz obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening AT dominikstrzelecki obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening AT agatagabryelska obstructivesleepapneaasanaccelerationtriggerofcellularsenescenceprocessesthroughtelomereshortening
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Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening

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