Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

The guided entry of tail-anchored proteins (GET) pathway assists in the delivery of such proteins to the ER. Here, the authors reveal that the pathway components Get4/5 probe a region near the ribosomal exit tunnel. Upon emergence of a client protein, Get4/5 recruits Sgt2 and initiates the targeting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying Zhang, Evelina De Laurentiis, Katherine E. Bohnsack, Mascha Wahlig, Namit Ranjan, Simon Gruseck, Philipp Hackert, Tina Wölfle, Marina V. Rodnina, Blanche Schwappach, Sabine Rospert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96ddf33632654134a1b5c75874d99b55
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96ddf33632654134a1b5c75874d99b55
record_format	dspace
spelling	oai:doaj.org-article:96ddf33632654134a1b5c75874d99b552021-12-02T14:06:10ZRibosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast10.1038/s41467-021-20981-32041-1723https://doaj.org/article/96ddf33632654134a1b5c75874d99b552021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20981-3https://doaj.org/toc/2041-1723The guided entry of tail-anchored proteins (GET) pathway assists in the delivery of such proteins to the ER. Here, the authors reveal that the pathway components Get4/5 probe a region near the ribosomal exit tunnel. Upon emergence of a client protein, Get4/5 recruits Sgt2 and initiates the targeting phase of the pathway.Ying ZhangEvelina De LaurentiisKatherine E. BohnsackMascha WahligNamit RanjanSimon GruseckPhilipp HackertTina WölfleMarina V. RodninaBlanche SchwappachSabine RospertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Zhang Evelina De Laurentiis Katherine E. Bohnsack Mascha Wahlig Namit Ranjan Simon Gruseck Philipp Hackert Tina Wölfle Marina V. Rodnina Blanche Schwappach Sabine Rospert Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
description	The guided entry of tail-anchored proteins (GET) pathway assists in the delivery of such proteins to the ER. Here, the authors reveal that the pathway components Get4/5 probe a region near the ribosomal exit tunnel. Upon emergence of a client protein, Get4/5 recruits Sgt2 and initiates the targeting phase of the pathway.
format	article
author	Ying Zhang Evelina De Laurentiis Katherine E. Bohnsack Mascha Wahlig Namit Ranjan Simon Gruseck Philipp Hackert Tina Wölfle Marina V. Rodnina Blanche Schwappach Sabine Rospert
author_facet	Ying Zhang Evelina De Laurentiis Katherine E. Bohnsack Mascha Wahlig Namit Ranjan Simon Gruseck Philipp Hackert Tina Wölfle Marina V. Rodnina Blanche Schwappach Sabine Rospert
author_sort	Ying Zhang
title	Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
title_short	Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
title_full	Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
title_fullStr	Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
title_full_unstemmed	Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast
title_sort	ribosome-bound get4/5 facilitates the capture of tail-anchored proteins by sgt2 in yeast
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96ddf33632654134a1b5c75874d99b55
work_keys_str_mv	AT yingzhang ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT evelinadelaurentiis ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT katherineebohnsack ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT maschawahlig ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT namitranjan ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT simongruseck ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT philipphackert ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT tinawolfle ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT marinavrodnina ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT blancheschwappach ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast AT sabinerospert ribosomeboundget45facilitatesthecaptureoftailanchoredproteinsbysgt2inyeast
_version_	1718392036212604928

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

Ejemplares similares