Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.

Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal preventive strategies for healthcare workers during the COVID-19 pandemic remain poorly understood. Here we report the results of a cohort study that included pre- and asy...

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Autores principales:	Daniel Sanchez-Taltavull, Violeta Castelo-Szekely, Shaira Murugan, Jonathan I D Hamley, Tim Rollenske, Stephanie C Ganal-Vonarburg, Isabel Büchi, Adrian Keogh, Hai Li, Lilian Salm, Daniel Spari, Bahtiyar Yilmaz, Jakob Zimmermann, Michael Gerfin, Edgar Roldan, Guido Beldi, UVCM-COVID researchers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96dfdb78f1894c1dbc3241702a9ad3bb
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spelling	oai:doaj.org-article:96dfdb78f1894c1dbc3241702a9ad3bb2021-12-02T20:16:25ZRegular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.1932-620310.1371/journal.pone.0258700https://doaj.org/article/96dfdb78f1894c1dbc3241702a9ad3bb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258700https://doaj.org/toc/1932-6203Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal preventive strategies for healthcare workers during the COVID-19 pandemic remain poorly understood. Here we report the results of a cohort study that included pre- and asymptomatic healthcare workers. A weekly testing regime has been performed in this cohort since the beginning of the COVID-19 pandemic to identify infected healthcare workers. Based on these observations we have developed a mathematical model of SARS-CoV-2 transmission that integrates the sources of infection from inside and outside the hospital. The data were used to study how regular testing and a desynchronisation protocol are effective in preventing transmission of COVID-19 infection at work, and compared both strategies in terms of workforce availability and cost-effectiveness. We showed that case incidence among healthcare workers is higher than would be explained solely by community infection. Furthermore, while testing and desynchronisation protocols are both effective in preventing nosocomial transmission, regular testing maintains work productivity with implementation costs.Daniel Sanchez-TaltavullVioleta Castelo-SzekelyShaira MuruganJonathan I D HamleyTim RollenskeStephanie C Ganal-VonarburgIsabel BüchiAdrian KeoghHai LiLilian SalmDaniel SpariBahtiyar YilmazJakob ZimmermannMichael GerfinEdgar RoldanGuido BeldiUVCM-COVID researchersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Sanchez-Taltavull Violeta Castelo-Szekely Shaira Murugan Jonathan I D Hamley Tim Rollenske Stephanie C Ganal-Vonarburg Isabel Büchi Adrian Keogh Hai Li Lilian Salm Daniel Spari Bahtiyar Yilmaz Jakob Zimmermann Michael Gerfin Edgar Roldan Guido Beldi UVCM-COVID researchers Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
description	Protecting healthcare professionals is crucial in maintaining a functioning healthcare system. The risk of infection and optimal preventive strategies for healthcare workers during the COVID-19 pandemic remain poorly understood. Here we report the results of a cohort study that included pre- and asymptomatic healthcare workers. A weekly testing regime has been performed in this cohort since the beginning of the COVID-19 pandemic to identify infected healthcare workers. Based on these observations we have developed a mathematical model of SARS-CoV-2 transmission that integrates the sources of infection from inside and outside the hospital. The data were used to study how regular testing and a desynchronisation protocol are effective in preventing transmission of COVID-19 infection at work, and compared both strategies in terms of workforce availability and cost-effectiveness. We showed that case incidence among healthcare workers is higher than would be explained solely by community infection. Furthermore, while testing and desynchronisation protocols are both effective in preventing nosocomial transmission, regular testing maintains work productivity with implementation costs.
format	article
author	Daniel Sanchez-Taltavull Violeta Castelo-Szekely Shaira Murugan Jonathan I D Hamley Tim Rollenske Stephanie C Ganal-Vonarburg Isabel Büchi Adrian Keogh Hai Li Lilian Salm Daniel Spari Bahtiyar Yilmaz Jakob Zimmermann Michael Gerfin Edgar Roldan Guido Beldi UVCM-COVID researchers
author_facet	Daniel Sanchez-Taltavull Violeta Castelo-Szekely Shaira Murugan Jonathan I D Hamley Tim Rollenske Stephanie C Ganal-Vonarburg Isabel Büchi Adrian Keogh Hai Li Lilian Salm Daniel Spari Bahtiyar Yilmaz Jakob Zimmermann Michael Gerfin Edgar Roldan Guido Beldi UVCM-COVID researchers
author_sort	Daniel Sanchez-Taltavull
title	Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
title_short	Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
title_full	Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
title_fullStr	Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
title_full_unstemmed	Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.
title_sort	regular testing of asymptomatic healthcare workers identifies cost-efficient sars-cov-2 preventive measures.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/96dfdb78f1894c1dbc3241702a9ad3bb
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Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures.

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