Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes

Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes

Abstract Background We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-established genetic risk alleles on transcription at single-cell resolu...

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Autores principales: Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld, Timothy B. Niewold
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Diseases of the musculoskeletal system
RC925-935
Acceso en línea:https://doaj.org/article/96e352fc33f345cd81032036828010a0
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