Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

Opening of the UNC-64/syntaxin closed conformation by UNC-13/Munc13 to form the neuronal SNARE complex is critical for neurotransmitter release. Here the authors show that facilitating the opening of syntaxin enhances exocytosis not only in unc-13 nulls as well as in diverse C. elegans mutants.

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Autores principales:	Chi-Wei Tien, Bin Yu, Mengjia Huang, Karolina P. Stepien, Kyoko Sugita, Xiaoyu Xie, Liping Han, Philippe P. Monnier, Mei Zhen, Josep Rizo, Shangbang Gao, Shuzo Sugita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96e3ef5c27104c518147da2404c45bad
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spelling	oai:doaj.org-article:96e3ef5c27104c518147da2404c45bad2021-12-02T16:49:28ZOpen syntaxin overcomes exocytosis defects of diverse mutants in C. elegans10.1038/s41467-020-19178-x2041-1723https://doaj.org/article/96e3ef5c27104c518147da2404c45bad2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19178-xhttps://doaj.org/toc/2041-1723Opening of the UNC-64/syntaxin closed conformation by UNC-13/Munc13 to form the neuronal SNARE complex is critical for neurotransmitter release. Here the authors show that facilitating the opening of syntaxin enhances exocytosis not only in unc-13 nulls as well as in diverse C. elegans mutants.Chi-Wei TienBin YuMengjia HuangKarolina P. StepienKyoko SugitaXiaoyu XieLiping HanPhilippe P. MonnierMei ZhenJosep RizoShangbang GaoShuzo SugitaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chi-Wei Tien Bin Yu Mengjia Huang Karolina P. Stepien Kyoko Sugita Xiaoyu Xie Liping Han Philippe P. Monnier Mei Zhen Josep Rizo Shangbang Gao Shuzo Sugita Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
description	Opening of the UNC-64/syntaxin closed conformation by UNC-13/Munc13 to form the neuronal SNARE complex is critical for neurotransmitter release. Here the authors show that facilitating the opening of syntaxin enhances exocytosis not only in unc-13 nulls as well as in diverse C. elegans mutants.
format	article
author	Chi-Wei Tien Bin Yu Mengjia Huang Karolina P. Stepien Kyoko Sugita Xiaoyu Xie Liping Han Philippe P. Monnier Mei Zhen Josep Rizo Shangbang Gao Shuzo Sugita
author_facet	Chi-Wei Tien Bin Yu Mengjia Huang Karolina P. Stepien Kyoko Sugita Xiaoyu Xie Liping Han Philippe P. Monnier Mei Zhen Josep Rizo Shangbang Gao Shuzo Sugita
author_sort	Chi-Wei Tien
title	Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
title_short	Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
title_full	Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
title_fullStr	Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
title_full_unstemmed	Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans
title_sort	open syntaxin overcomes exocytosis defects of diverse mutants in c. elegans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/96e3ef5c27104c518147da2404c45bad
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Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

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